ccn2a cellular communication network factor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccn2aprovided by ZNC
Official Full Name: cellular communication network factor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-102
See related: Ensembl:ENSDARG00000042934 AllianceGenome:ZFIN:ZDB-GENE-030131-102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctgf; ctgfa; hm:zeh1559; wu:fl25c03; zgc:136644; si:dkey-266k12.4
Summary: Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within with a negative effect on definitive hemopoiesis. Acts upstream of or within several processes, including endoderm development; notochord development; and regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; fin; head; mesoderm; and spinal cord. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (25340814..25343490)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (25441724..25444400)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish.
Title: Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish.
Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.
Title: Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
Title: Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
Title: Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Title: The physiological role of CTGF/CCN2 in zebrafish notochond development and biological analysis of the proximal promoter region.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CCN family member 2a

Names: connective tissue growth factor a; zCTGF-c20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015041.2 → NP_001015041.1 CCN family member 2a precursor

See identical proteins and their annotated locations for NP_001015041.1

Status: PROVISIONAL

Source sequence(s)

BX323010

UniProtKB/TrEMBL

A0A0B5JK78, Q5RI33

Related

ENSDARP00000063027.5, ENSDART00000063028.6

Conserved Domains (4) summary

smart00209
Location:198 → 239

TSP1; Thrombospondin type 1 repeats

smart00214
Location:99 → 158

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:249 → 340

GHB_like; Glycoprotein hormone beta chain homologues