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phb prohibitin [ Danio rerio (zebrafish) ]

Gene ID: 321346, updated on 11-Apr-2024

Summary

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Official Symbol
phbprovided by ZNC
Official Full Name
prohibitinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6577
See related
Ensembl:ENSDARG00000057414 AllianceGenome:ZFIN:ZDB-GENE-030131-6577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa18f07; fb09f05; sr:nyz128; wu:fa18f07; wu:fb09f05
Summary
Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane and plasma membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and musculature system. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB (prohibitin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15736799..15746995)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15587000..15597197)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene proline-rich transmembrane protein 2-like Neighboring gene major vault protein Neighboring gene zinc finger protein 652 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
  2. Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Hoffmann JL, et al. Aquat Toxicol, 2006 Sep 12. PMID 16872691
  3. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
  4. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
  5. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prohibitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201297.1 → NP_958454.1  prohibitin

    See identical proteins and their annotated locations for NP_958454.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055384
    UniProtKB/TrEMBL
    A0A0B5JQ92, F6NM96, Q7T1D8
    Related
    ENSDARP00000074525.4, ENSDART00000080075.5
    Conserved Domains (2) summary
    smart00244
    Location:25 → 186
    PHB; prohibitin homologues
    cd03401
    Location:26 → 220
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    15736799..15746995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163797.4 → XP_005163854.1  prohibitin isoform X1

    UniProtKB/TrEMBL
    A0A8M2BB12
    Conserved Domains (2) summary
    smart00244
    Location:63 → 224
    PHB; prohibitin homologues
    cd03401
    Location:64 → 258
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
Heading Accession and Version

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