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Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 [ Mus musculus (house mouse) ]

Gene ID: 320997, updated on 5-Mar-2024

Summary

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Official Symbol
Cyp4f39provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily f, polypeptide 39provided by MGI
Primary source
MGI:MGI:2445210
See related
Ensembl:ENSMUSG00000061126 AllianceGenome:MGI:2445210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732474A20Rik
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 5. Orthologous to human CYP4F22 (cytochrome P450 family 4 subfamily F member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 10.0), testis adult (RPKM 9.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.59 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32671670..32712294)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32452697..32493320)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene RAS protein activator like 3 Neighboring gene predicted gene, 41569 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32561046-32561233 Neighboring gene STARR-seq mESC enhancer starr_42380 Neighboring gene STARR-seq mESC enhancer starr_42381 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17 Neighboring gene STARR-seq mESC enhancer starr_42382 Neighboring gene STARR-seq mESC enhancer starr_42383 Neighboring gene STARR-positive B cell enhancer ABC_E8998 Neighboring gene STARR-seq mESC enhancer starr_42384 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease. Miyamoto M, et al. Elife, 2020 Apr 7. PMID 32252890, Free PMC Article
  2. Diverse meibum lipids produced by Awat1 and Awat2 are important for stabilizing tear film and protecting the ocular surface. Sawai M, et al. iScience, 2021 May 21. PMID 34113821, Free PMC Article
  3. Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice. Kato A, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2022 Feb. PMID 34813948
  4. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production. Miyamoto M, et al. J Invest Dermatol, 2020 Feb. PMID 31356814
  5. PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. Pichery M, et al. Hum Mol Genet, 2017 May 15. PMID 28369476

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production.
    Title: Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily E, polypeptide 2 homolog
NP_796281.1
XP_006524486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177307.3 → NP_796281.1  cytochrome P450, family 2, subfamily E, polypeptide 2 homolog

    See identical proteins and their annotated locations for NP_796281.1

    Status: VALIDATED

    Source sequence(s)
    AK037192
    Consensus CDS
    CCDS28618.1
    UniProtKB/TrEMBL
    A6H653, Q8BGU0
    Related
    ENSMUSP00000158442.2, ENSMUST00000237491.2
    Conserved Domains (1) summary
    pfam00067
    Location:60 → 515
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32671670..32712294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524423.4 → XP_006524486.1  cytochrome P450, family 2, subfamily E, polypeptide 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_006524486.1

    UniProtKB/TrEMBL
    A6H653, Q8BGU0
    Related
    ENSMUSP00000003413.6, ENSMUST00000003413.7
    Conserved Domains (1) summary
    pfam00067
    Location:60 → 515
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

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