Itgb8 integrin beta 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb8provided by MGI
Official Full Name: integrin beta 8provided by MGI
Primary source: MGI:MGI:1338035
See related: Ensembl:ENSMUSG00000025321 AllianceGenome:MGI:1338035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4832412O06Rik
Summary: Predicted to enable extracellular matrix protein binding activity and integrin binding activity. Involved in regulation of transforming growth factor beta activation. Acts upstream of or within several processes, including Langerhans cell differentiation; ganglioside metabolic process; and hard palate development. Part of integrin alphav-beta8 complex. Is expressed in several structures, including axial skeleton; hindlimb phalanx; nervous system; reproductive system; and sensory organ. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 9.7), CNS E11.5 (RPKM 3.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F2; 12 63.48 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (119121757..119202891, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (119162803..119238276, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin beta8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-beta1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Title: Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
The beta8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development.
Title: The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development.
Integrin alphavbeta8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Title: Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Regulatory T cells promote cancer immune-escape through integrin alphavbeta8-mediated TGF-beta activation.
Title: Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
miR222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.
Title: miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.
These data identify novel roles for alphaVbeta8 and TGFbeta signaling in coordinating microgliogenesis with brain development and implicate abnormally programmed microglia or their products in human neurodevelopmental disorders that share this neuropathology.
Title: Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF. Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.
Title: Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
data show that the combination of cell lineage, immune mediators and both dietary and microbe-derived environmental factors shape intestinal dendritic cells into critical gatekeepers of TGF-beta-dependent immune responses through regulation of beta8 integrin expression
Title: β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.
Title: Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Nrp1 in endothelial cells suppresses TGFbeta activation and signaling by forming intercellular protein complexes with beta8 integrin.
Title: Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

MARC_23311-23312:1024579300:3 (e-PCR)
- UniSTS:268671

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Langerhans cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within ganglioside metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hard palate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to virus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphav-beta8 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta8 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177290.4 → NP_796264.2 integrin beta-8 precursor

See identical proteins and their annotated locations for NP_796264.2

Status: VALIDATED

Source sequence(s)

AC140349, AC142263

Consensus CDS

CCDS36580.1

UniProtKB/Swiss-Prot

Q0VBD0

Related

ENSMUSP00000026360.9, ENSMUST00000026360.9

Conserved Domains (2) summary

smart00187
Location:54 → 469

INB; Integrin beta subunits (N-terminal portion of extracellular region)

NF033759
Location:470 → 642

exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

119121757..119202891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157503.1 → XP_036013396.1 integrin beta-8 isoform X1

Conserved Domains (2) summary

NF033759
Location:335 → 507

exchanger_TraA; outer membrane exchange protein TraA

cl00057
Location:1 → 334

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...