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Mysm1 myb-like, SWIRM and MPN domains 1 [ Mus musculus (house mouse) ]

Gene ID: 320713, updated on 21-Apr-2024

Summary

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Official Symbol
Mysm1provided by MGI
Official Full Name
myb-like, SWIRM and MPN domains 1provided by MGI
Primary source
MGI:MGI:2444584
See related
Ensembl:ENSMUSG00000062627 AllianceGenome:MGI:2444584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130067A03Rik; C530050H10Rik
Summary
Predicted to enable histone binding activity; peptidase activity; and transcription coactivator activity. Acts upstream of or within pigmentation; regulation of cell migration; and regulation of hair follicle development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in metanephros. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.5), CNS E11.5 (RPKM 4.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C5; 4 43.34 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94830274..94867392, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94942037..94979155, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene equatorin, sperm acrosome associated Neighboring gene predicted gene 12693 Neighboring gene STARR-seq mESC enhancer starr_10795 Neighboring gene STARR-positive B cell enhancer ABC_E2697 Neighboring gene STARR-seq mESC enhancer starr_10796 Neighboring gene STARR-positive B cell enhancer ABC_E6190 Neighboring gene STARR-positive B cell enhancer mm9_chr4:94674887-94675187 Neighboring gene predicted gene 12694 Neighboring gene STARR-positive B cell enhancer ABC_E6191 Neighboring gene STARR-positive B cell enhancer ABC_E36 Neighboring gene jun proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma. Lin YH, et al. J Cell Mol Med, 2021 Jul. PMID 34114734, Free PMC Article
  2. MYSM1/2A-DUB is an epigenetic regulator in human melanoma and contributes to tumor cell growth. Wilms C, et al. Oncotarget, 2017 Sep 15. PMID 28978033, Free PMC Article
  3. Mysm1 expression in the bone marrow niche is not essential for hematopoietic maintenance. Petrov JC, et al. Exp Hematol, 2017 Mar. PMID 27833034
  4. Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation. Li P, et al. Sci Rep, 2016 Feb 26. PMID 26915790, Free PMC Article
  5. Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1. Jiang XX, et al. Sci Rep, 2015 Sep 8. PMID 26348977, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation.
    Title: Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation.
  2. Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
    Title: Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
  3. Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma.
    Title: Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma.
  4. MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction.
    Title: MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction.
  5. Study indicates a role of histone H2A deubiquitinase MYSM1 (Mysm1) in regulating the immunomodulatory activities of adipose-derived stem cells (ASCs) by targeting miR-150.
    Title: Mysm1 epigenetically regulates the immunomodulatory function of adipose-derived stem cells in part by targeting miR-150.
  6. This study provides a complete overview of the polyubiquitins in NOD2:RIP2 signaling and reveal MYSM1 as a central negative regulator restricting these polyubiquitins to prevent excessive inflammation.
    Title: The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex.
  7. Mysm1 is a critical epigenetic regulator of epidermal development and ESC specification through interference with p53-mediated apoptosis and cell cycle inhibition-and potentially modification of p63-regulated programs-whereas ESC maintenance later in adult life may be compensated through yet to be investigated mechanisms.
    Title: 2A-DUB/Mysm1 Regulates Epidermal Development in Part by Suppressing p53-Mediated Programs.
  8. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
    Title: Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development.
  9. MYSM1 activity at the prepro-B cell stage of development is important for the normal programming of B cell responses to stimulation once they complete their maturation process.
    Title: MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response.
  10. Overall we conclude that Mysm1 expression within the niche is not essential for the maintenance of hematopoietic homeostasis.
    Title: Mysm1 expression in the bone marrow niche is not essential for hematopoietic maintenance.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2A deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
deubiquitinase MYSM1
Names
2A-DUB
histone H2A deubiquitinase MYSM1
myb-like, SWIRM and MPN domain-containing protein 1
NP_796213.2
XP_006503233.2
XP_017175747.1
XP_017175748.1
XP_017175749.1
XP_017175750.1
XP_030109470.1
XP_030109472.1
XP_036020079.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177239.4 → NP_796213.2  deubiquitinase MYSM1

    See identical proteins and their annotated locations for NP_796213.2

    Status: VALIDATED

    Source sequence(s)
    AL732611
    Consensus CDS
    CCDS18363.1
    UniProtKB/Swiss-Prot
    A2AJE3, B9EKJ6, Q3TPV7, Q69Z66, Q8BRP5, Q8C4N1
    Related
    ENSMUSP00000075269.4, ENSMUST00000075872.4
    Conserved Domains (4) summary
    cd08067
    Location:562 → 744
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    smart00717
    Location:117 → 161
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:117 → 160
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    94830274..94867392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503170.4 → XP_006503233.2  deubiquitinase MYSM1 isoform X7

    Conserved Domains (3) summary
    cd08067
    Location:562 → 705
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  2. XM_036164186.1 → XP_036020079.1  deubiquitinase MYSM1 isoform X3

    Conserved Domains (3) summary
    cd08067
    Location:562 → 744
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  3. XM_017320261.2 → XP_017175750.1  deubiquitinase MYSM1 isoform X6

    Conserved Domains (3) summary
    cd08067
    Location:562 → 710
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  4. XM_017320259.2 → XP_017175748.1  deubiquitinase MYSM1 isoform X2

    Conserved Domains (3) summary
    cd08067
    Location:562 → 749
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  5. XM_017320258.2 → XP_017175747.1  deubiquitinase MYSM1 isoform X1

    Conserved Domains (3) summary
    cd08067
    Location:562 → 749
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  6. XM_030253612.2 → XP_030109472.1  deubiquitinase MYSM1 isoform X8

    Conserved Domains (2) summary
    cd08067
    Location:313 → 495
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam04433
    Location:124 → 203
    SWIRM; SWIRM domain

  7. XM_030253610.2 → XP_030109470.1  deubiquitinase MYSM1 isoform X5

    Conserved Domains (3) summary
    cd08067
    Location:562 → 705
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

  8. XM_017320260.3 → XP_017175749.1  deubiquitinase MYSM1 isoform X4

    Conserved Domains (3) summary
    cd08067
    Location:562 → 710
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
    pfam00249
    Location:116 → 160
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam04433
    Location:373 → 452
    SWIRM; SWIRM domain

RNA

  1. XR_003954970.2 RNA Sequence

  2. XR_003954969.2 RNA Sequence

  3. XR_003954971.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z66.2 GenPept UniProtKB/Swiss-Prot:Q69Z66

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