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Tafa4 TAFA chemokine like family member 4 [ Mus musculus (house mouse) ]

Gene ID: 320701, updated on 21-Apr-2024

Summary

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Official Symbol
Tafa4provided by MGI
Official Full Name
TAFA chemokine like family member 4provided by MGI
Primary source
MGI:MGI:2444563
See related
Ensembl:ENSMUSG00000046500 AllianceGenome:MGI:2444563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tafa-4; Fam19a4; C130034I18Rik; Fam19a4 Tafa-4
Summary
Enables receptor ligand activity. Involved in several processes, including macrophage chemotaxis; phagocytosis; and superoxide anion generation. Acts upstream of or within regulation of membrane potential and regulation of sensory perception of pain. Located in extracellular space. Is expressed in central nervous system; dorsal root ganglion; inner ear; and tooth. Orthologous to human TAFA4 (TAFA chemokine like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
6 D3; 6 44.8 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (96808167..97037452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (96831206..97060411, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene predicted gene, 22971 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene STARR-seq mESC enhancer starr_16776 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene predicted gene, 26175 Neighboring gene TATA element modulatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction. Kambrun C, et al. Cell Rep, 2018 Mar 13. PMID 29539418
  2. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current. Yoo S, et al. Cell Rep, 2021 Oct 26. PMID 34706225
  3. Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner. Bohic M, et al. Cell Rep, 2020 Jan 21. PMID 31968239
  4. TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice. Delfini MC, et al. Cell Rep, 2013 Oct 31. PMID 24139797
  5. Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells. Zhou C, et al. Clin Exp Immunol, 2023 Mar 8. PMID 36368013, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells.
    Title: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.
  2. TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current.
    Title: TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K(+) current.
  3. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
    Title: Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
  4. TAFA4 is required to maintain the normal threshold of injury-induced mechanical and chemical pain hypersensitivity and strongly support a potential role of TAFA4 as a potent analgesic in the settings of inflammation and neuropathy.
    Title: TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC107151

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in superoxide anion generation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chemokine-like protein TAFA-4
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
family with sequence similarity 19, member A4
protein FAM19A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177233.5 → NP_796207.2  chemokine-like protein TAFA-4 precursor

    See identical proteins and their annotated locations for NP_796207.2

    Status: VALIDATED

    Source sequence(s)
    AC133086, AC160399
    Consensus CDS
    CCDS51858.1
    UniProtKB/Swiss-Prot
    Q5FWC0, Q7TPG5, Q8BV02
    Related
    ENSMUSP00000086710.5, ENSMUST00000089295.6
    Conserved Domains (1) summary
    pfam12020
    Location:46 → 133
    TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    96808167..97037452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166237.1 → XP_036022130.1  chemokine-like protein TAFA-4 isoform X2

    UniProtKB/Swiss-Prot
    Q5FWC0, Q7TPG5, Q8BV02
    Conserved Domains (1) summary
    pfam12020
    Location:46 → 133
    TAFA; TAFA family

  2. XM_036166236.1 → XP_036022129.1  chemokine-like protein TAFA-4 isoform X2

    UniProtKB/Swiss-Prot
    Q5FWC0, Q7TPG5, Q8BV02
    Conserved Domains (1) summary
    pfam12020
    Location:46 → 133
    TAFA; TAFA family

  3. XM_017321648.3 → XP_017177137.1  chemokine-like protein TAFA-4 isoform X2

    UniProtKB/Swiss-Prot
    Q5FWC0, Q7TPG5, Q8BV02
    Conserved Domains (1) summary
    pfam12020
    Location:46 → 133
    TAFA; TAFA family

  4. XM_030255465.1 → XP_030111325.1  chemokine-like protein TAFA-4 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:77 → 164
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPG5.1 GenPept UniProtKB/Swiss-Prot:Q7TPG5

Gene LinkOut

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