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Dctd dCMP deaminase [ Mus musculus (house mouse) ]

Gene ID: 320685, updated on 11-Apr-2024

Summary

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Official Symbol
Dctdprovided by MGI
Official Full Name
dCMP deaminaseprovided by MGI
Primary source
MGI:MGI:2444529
See related
Ensembl:ENSMUSG00000031562 AllianceGenome:MGI:2444529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030466N05Rik
Summary
Predicted to enable dCMP deaminase activity and identical protein binding activity. Predicted to be involved in dTMP biosynthetic process and dUMP biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and respiratory system. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 14.2), CNS E11.5 (RPKM 7.8) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B1.1- B1.2; 8 26.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48552127..48594702)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (48099092..48141667)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene STARR-seq mESC enhancer starr_21423 Neighboring gene predicted gene, 31984 Neighboring gene STARR-seq mESC enhancer starr_21426 Neighboring gene predicted gene, 32052 Neighboring gene STARR-seq mESC enhancer starr_21427 Neighboring gene STARR-seq mESC enhancer starr_21428 Neighboring gene STARR-seq mESC enhancer starr_21430 Neighboring gene predicted gene, 39174 Neighboring gene STARR-seq mESC enhancer starr_21431 Neighboring gene STARR-seq mESC enhancer starr_21432 Neighboring gene STARR-seq mESC enhancer starr_21434 Neighboring gene predicted gene, 32194 Neighboring gene predicted gene, 51559

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside salvage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
deoxycytidylate deaminase
NP_001154987.2
NP_001154988.2
NP_848903.3
XP_006509505.1
XP_036009996.1
XP_036009997.1
XP_036009998.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161515.2 → NP_001154987.2  deoxycytidylate deaminase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC164420
    Consensus CDS
    CCDS22302.2
    UniProtKB/Swiss-Prot
    Q8BP55, Q8K2D6
    Related
    ENSMUSP00000033966.8, ENSMUST00000033966.14
    Conserved Domains (1) summary
    cd01286
    Location:17 → 138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  2. NM_001161516.2 → NP_001154988.2  deoxycytidylate deaminase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC164420
    Consensus CDS
    CCDS22302.2
    UniProtKB/Swiss-Prot
    Q8BP55, Q8K2D6
    Related
    ENSMUSP00000133445.3, ENSMUST00000174278.9
    Conserved Domains (1) summary
    cd01286
    Location:17 → 138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  3. NM_178788.5 → NP_848903.3  deoxycytidylate deaminase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC164420
    Consensus CDS
    CCDS22302.2
    UniProtKB/Swiss-Prot
    Q8BP55, Q8K2D6
    Related
    ENSMUSP00000126733.4, ENSMUST00000170263.10
    Conserved Domains (1) summary
    cd01286
    Location:17 → 138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

RNA

  1. NR_027759.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC164420, AI327164, AK077663, AV323917, BB193146, BB621273, BQ572929, BY014599
    Related
    ENSMUST00000174818.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    48552127..48594702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154105.1 → XP_036009998.1  deoxycytidylate deaminase isoform X1

    Conserved Domains (1) summary
    cd01286
    Location:23 → 126
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  2. XM_036154103.1 → XP_036009996.1  deoxycytidylate deaminase isoform X1

    Conserved Domains (1) summary
    cd01286
    Location:23 → 126
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  3. XM_036154104.1 → XP_036009997.1  deoxycytidylate deaminase isoform X1

    Conserved Domains (1) summary
    cd01286
    Location:23 → 126
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  4. XM_006509442.4 → XP_006509505.1  deoxycytidylate deaminase isoform X2

    See identical proteins and their annotated locations for XP_006509505.1

    UniProtKB/TrEMBL
    G3X908
    Conserved Domains (1) summary
    cd01286
    Location:23 → 144
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

RNA

  1. XR_003947308.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2D6.1 GenPept UniProtKB/Swiss-Prot:Q8K2D6

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