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Rasal3 RAS protein activator like 3 [ Mus musculus (house mouse) ]

Gene ID: 320484, updated on 21-Apr-2024

Summary

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Official Symbol
Rasal3provided by MGI
Official Full Name
RAS protein activator like 3provided by MGI
Primary source
MGI:MGI:2444128
See related
Ensembl:ENSMUSG00000052142 AllianceGenome:MGI:2444128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430107D22Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and positive regulation of NK T cell proliferation. Predicted to be located in cytoplasm and cytoplasmic side of membrane. Is expressed in thymus primordium. Orthologous to human RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 113.1), spleen adult (RPKM 50.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32609633..32622586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32390659..32403582, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8-like Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene widely-interspaced zinc finger motifs Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene predicted gene, 53995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 41569 Neighboring gene peptidoglycan recognition protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32561046-32561233 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rasal3-mediated T cell survival is essential for inflammatory responses. Muro R, et al. Biochem Biophys Res Commun, 2018 Jan 29. PMID 29291408
  2. The Ras GTPase-activating protein Rasal3 supports survival of naive T cells. Muro R, et al. PLoS One, 2015. PMID 25793935, Free PMC Article
  3. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Saito S, et al. Front Immunol, 2021. PMID 34777356, Free PMC Article
  4. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. Saito S, et al. Eur J Immunol, 2015 May. PMID 25652366
  5. Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis. Yu X, et al. Arthritis Res Ther, 2007. PMID 17244351, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
    Title: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
  2. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
    Title: RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.
  3. Collectively, Rasal3 controls the magnitude of inflammatory responses through the survival of both naive T cells and activated T cells in vivo.
    Title: Rasal3-mediated T cell survival is essential for inflammatory responses.
  4. Rasal3 is required for in vivo survival of peripheral naive T cells, contributing to the maintenance of optimal T cell numbers.
    Title: The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.
  5. results suggest that RASAL3 plays an important role in the expansion and functions of NKT cells in the liver by negatively regulating Ras/Erk signaling
    Title: RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAS protein activator like-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347343.2 → NP_001334272.1  RAS protein activator like-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT485616
    Consensus CDS
    CCDS84292.1
    UniProtKB/TrEMBL
    Q6KAS9
    Related
    ENSMUSP00000123141.2, ENSMUST00000137458.2

  2. NM_001374604.1 → NP_001361533.1  RAS protein activator like-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT485616
    UniProtKB/TrEMBL
    D3Z6Z7, Q6KAS9
    Related
    ENSMUSP00000116107.2, ENSMUST00000135618.8
    Conserved Domains (3) summary
    cd05136
    Location:424 → 747
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cl14603
    Location:300 → 432
    C2; C2 domain
    cl17171
    Location:181 → 326
    PH-like; Pleckstrin homology-like domain

  3. NM_001400382.1 → NP_001387311.1  RAS protein activator like-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT485616

  4. NM_178785.5 → NP_848900.2  RAS protein activator like-3 isoform 2

    See identical proteins and their annotated locations for NP_848900.2

    Status: VALIDATED

    Source sequence(s)
    CT485616
    Consensus CDS
    CCDS37556.1
    UniProtKB/Swiss-Prot
    A3KMM0, Q8C2A5, Q8C2K5, Q8C9R4, Q8CDB4
    UniProtKB/TrEMBL
    Q6KAS9
    Related
    ENSMUSP00000064084.8, ENSMUST00000063824.14
    Conserved Domains (3) summary
    cd05136
    Location:446 → 769
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cl14603
    Location:322 → 454
    C2; C2 domain
    cl17171
    Location:203 → 348
    PH-like; Pleckstrin homology-like domain

RNA

  1. NR_153797.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT485616

  2. NR_174479.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT485616

  3. NR_174480.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT485616

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32609633..32622586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524412.5 → XP_006524475.1  RAS protein activator like-3 isoform X1

    UniProtKB/TrEMBL
    Q6KAS9
    Conserved Domains (3) summary
    cd05136
    Location:470 → 793
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cl14603
    Location:346 → 478
    C2; C2 domain
    cl17171
    Location:227 → 372
    PH-like; Pleckstrin homology-like domain

  2. XM_030249844.2 → XP_030105704.1  RAS protein activator like-3 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J1U7
    Related
    ENSMUSP00000118738.2, ENSMUST00000136375.8
    Conserved Domains (3) summary
    cl02569
    Location:446 → 600
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:322 → 454
    C2; C2 domain
    cl17171
    Location:203 → 348
    PH-like; Pleckstrin homology-like domain

  3. XM_011246497.3 → XP_011244799.1  RAS protein activator like-3 isoform X2

    UniProtKB/TrEMBL
    A0A0R4J1U7
    Conserved Domains (3) summary
    cl02569
    Location:470 → 624
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:346 → 478
    C2; C2 domain
    cl17171
    Location:227 → 372
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_385337.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2K5.1 GenPept UniProtKB/Swiss-Prot:Q8C2K5

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