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Msrb3 methionine sulfoxide reductase B3 [ Mus musculus (house mouse) ]

Gene ID: 320183, updated on 21-Apr-2024

Summary

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Official Symbol
Msrb3provided by MGI
Official Full Name
methionine sulfoxide reductase B3provided by MGI
Primary source
MGI:MGI:2443538
See related
Ensembl:ENSMUSG00000051236 AllianceGenome:MGI:2443538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MsrB2; I-8-23; D430026P16Rik
Summary
Predicted to enable peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Predicted to be involved in protein repair. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; inner ear; jaw; limb; and skeleton. Used to study autosomal recessive nonsyndromic deafness 74. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 52.3), heart adult (RPKM 20.8) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 68.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120617005..120735132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120781100..120899011, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921513I03 gene Neighboring gene predicted gene, 35182 Neighboring gene STARR-seq mESC enhancer starr_28072 Neighboring gene STARR-seq mESC enhancer starr_28073 Neighboring gene predicted gene 15910 Neighboring gene STARR-positive B cell enhancer ABC_E581 Neighboring gene predicted gene 4473 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene LEM domain containing 3 Neighboring gene predicted gene, 50589

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss. Kim MA, et al. Antioxid Redox Signal, 2016 Apr 10. PMID 26649646, Free PMC Article
  2. Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways. Kwak GH, et al. Biochem Biophys Res Commun, 2016 May 13. PMID 27059143
  3. Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways. Lee E, et al. Arch Biochem Biophys, 2014 Apr 1. PMID 24583268
  4. MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3. Dai Y, et al. Oxid Med Cell Longev, 2020. PMID 32908641, Free PMC Article
  5. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Kim HY, et al. Biochem Biophys Res Commun, 2004 Aug 6. PMID 15249228

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.
    Title: MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.
  2. results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy
    Title: Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.
  3. data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency.
    Title: Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.
  4. MsrB3 deficiency activates the cell cycle inhibitors p21 and p27.
    Title: Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways.
  5. data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB isozymes. [MsrB3]
    Title: Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein repair ISO
Inferred from Sequence Orthology
more info
  
involved_in protein repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
methionine-R-sulfoxide reductase B3, mitochondrial
NP_001393328.1
NP_001393329.1
NP_796066.1
XP_036011713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406399.1 → NP_001393328.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138388

  2. NM_001406400.1 → NP_001393329.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138388
    UniProtKB/TrEMBL
    D3YUC9
    Related
    ENSMUSP00000115269.2, ENSMUST00000130950.2

  3. NM_177092.5 → NP_796066.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_796066.1

    Status: VALIDATED

    Source sequence(s)
    AC138388
    Consensus CDS
    CCDS24208.1
    UniProtKB/TrEMBL
    A0A0R4J139
    Related
    ENSMUSP00000089781.6, ENSMUST00000092143.12
    Conserved Domains (1) summary
    PRK00222
    Location:35 → 171
    PRK00222; peptide-methionine (R)-S-oxide reductase MsrB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120617005..120735132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155820.1 → XP_036011713.1  methionine-R-sulfoxide reductase B3, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU85.2 GenPept UniProtKB/Swiss-Prot:Q8BU85

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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