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Sybu syntabulin (syntaxin-interacting) [ Mus musculus (house mouse) ]

Gene ID: 319613, updated on 5-Mar-2024

Summary

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Official Symbol
Sybuprovided by MGI
Official Full Name
syntabulin (syntaxin-interacting)provided by MGI
Primary source
MGI:MGI:2442392
See related
Ensembl:ENSMUSG00000022340 AllianceGenome:MGI:2442392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Golsyn
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including axonal transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic activity. Predicted to act upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in dense body; intracellular membrane-bounded organelle; and microtubule. Predicted to be active in cytoplasmic microtubule and vesicle. Is expressed in alimentary system; central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 23.3), cerebellum adult (RPKM 12.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.2; 15 16.91 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44535252..44651466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (44671856..44788070, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney and hepatic disease 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10853 Neighboring gene STARR-positive B cell enhancer ABC_E7366 Neighboring gene STARR-seq mESC enhancer starr_38573 Neighboring gene estrogen receptor-binding fragment-associated gene 9 Neighboring gene STARR-seq mESC enhancer starr_38574 Neighboring gene RIKEN cDNA 2310069G16 gene Neighboring gene predicted gene, 33852 Neighboring gene Smg-5 homolog, nonsense mediated mRNA decay factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of the m-Golsyn gene and its expression in the mouse brain. Funakoshi E, et al. Gene Expr, 2006. PMID 16572588, Free PMC Article
  2. Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23. Funakoshi E, et al. Gene, 2005 Jan 3. PMID 15656992
  3. Expression of m-Golsyn/Syntabulin gene during mouse brain development. Funakoshi E, et al. Neurosci Lett, 2006 Aug 7. PMID 16750881
  4. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. Ying Y, et al. FEBS Lett, 2012 Oct 19. PMID 22975310
  5. TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. Ragancokova D, et al. J Clin Invest, 2014 Mar. PMID 24487590, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion
    Title: The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.
  2. results may indicate a significant role for this protein in neuronal cells and other types of cells such as those of the choroid plexus and ciliary body
    Title: Expression of m-Golsyn/Syntabulin gene during mouse brain development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1472, 5730410E15Rik, A830027B17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde neuronal dense core vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of synaptic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dense body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
syntabulin
Names
Golgi-localized syntaphilin-related protein
Golsyn/Syntabulin
syntaxin-1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032727.2 → NP_001027899.1  syntabulin isoform b

    See identical proteins and their annotated locations for NP_001027899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks two consecutive in-frame exons in the central coding region, compared to variant a. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC100730
    Consensus CDS
    CCDS37070.1
    UniProtKB/Swiss-Prot
    Q8BHS8
    Related
    ENSMUSP00000105898.2, ENSMUST00000110269.8
    Conserved Domains (1) summary
    pfam15290
    Location:167 → 357
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  2. NM_001285840.1 → NP_001272769.1  syntabulin isoform c

    See identical proteins and their annotated locations for NP_001272769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant a. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AB232447, AK220268
    Consensus CDS
    CCDS37071.1
    UniProtKB/Swiss-Prot
    Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BHS8, Q8BI27
    Related
    ENSMUSP00000153759.2, ENSMUST00000228057.2
    Conserved Domains (1) summary
    pfam15290
    Location:239 → 429
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  3. NM_001285841.1 → NP_001272770.1  syntabulin isoform d

    See identical proteins and their annotated locations for NP_001272770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at a downstream start codon. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AB232447, AC100730, CO425611
    UniProtKB/Swiss-Prot
    Q8BHS8
    Conserved Domains (1) summary
    pfam15290
    Location:5 → 300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  4. NM_001285842.1 → NP_001272771.1  syntabulin isoform d

    See identical proteins and their annotated locations for NP_001272771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at a downstream start codon. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AB232447, AC100730, CF724604
    UniProtKB/Swiss-Prot
    Q8BHS8
    Conserved Domains (1) summary
    pfam15290
    Location:5 → 300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  5. NM_001285843.1 → NP_001272772.1  syntabulin isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (g) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (e) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB232447, AC100730, BY299369
    UniProtKB/Swiss-Prot
    Q8BHS8
    Conserved Domains (1) summary
    pfam15290
    Location:138 → 328
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  6. NM_001285844.1 → NP_001272773.1  syntabulin isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (h) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (f) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB232447, AC100730, CO425611, CX224257
    UniProtKB/Swiss-Prot
    Q8BHS8
    Conserved Domains (1) summary
    pfam15290
    Location:102 → 292
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  7. NM_001358582.2 → NP_001345511.1  syntabulin isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (i) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (g) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC100730
    Consensus CDS
    CCDS88763.1
    Related
    ENSMUSP00000154372.2, ENSMUST00000227305.2
    Conserved Domains (1) summary
    pfam15290
    Location:238 → 428
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  8. NM_001358583.1 → NP_001345512.1  syntabulin isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (j) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (h) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC100730
    Related
    ENSMUST00000226825.2
    Conserved Domains (1) summary
    pfam15290
    Location:93 → 374
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  9. NM_001358584.1 → NP_001345513.1  syntabulin isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (k) has multiple differences, compared to variant 1. These differences result in a distinct 5'UTR and cause translation initiation at an alternate start codon. The encoded isoform (i) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC100730
    Conserved Domains (1) summary
    pfam15290
    Location:93 → 374
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  10. NM_001416535.1 → NP_001403464.1  syntabulin isoform i

    Status: VALIDATED

    Source sequence(s)
    AC100730

  11. NM_001416536.1 → NP_001403465.1  syntabulin isoform j

    Status: VALIDATED

    Source sequence(s)
    AC100730

  12. NM_001416537.1 → NP_001403466.1  syntabulin isoform k

    Status: VALIDATED

    Source sequence(s)
    AC100730

  13. NM_001416538.1 → NP_001403467.1  syntabulin isoform l

    Status: VALIDATED

    Source sequence(s)
    AC100730

  14. NM_001416539.1 → NP_001403468.1  syntabulin isoform m

    Status: VALIDATED

    Source sequence(s)
    AC100730

  15. NM_001416540.1 → NP_001403469.1  syntabulin isoform n

    Status: VALIDATED

    Source sequence(s)
    AC100730

  16. NM_001416541.1 → NP_001403470.1  syntabulin isoform o

    Status: VALIDATED

    Source sequence(s)
    AC100730

  17. NM_001416542.1 → NP_001403471.1  syntabulin isoform h

    Status: VALIDATED

    Source sequence(s)
    AC100730

  18. NM_001416543.1 → NP_001403472.1  syntabulin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC100730

  19. NM_176998.5 → NP_795972.2  syntabulin isoform a

    See identical proteins and their annotated locations for NP_795972.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC100730
    Consensus CDS
    CCDS37069.1
    UniProtKB/Swiss-Prot
    Q8BHS8
    Related
    ENSMUSP00000087511.5, ENSMUST00000090057.6
    Conserved Domains (1) summary
    pfam15290
    Location:367 → 557
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  20. NM_178765.4 → NP_848880.2  syntabulin isoform c

    See identical proteins and their annotated locations for NP_848880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at a downstream start codon, compared to variant a. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AC100730
    Consensus CDS
    CCDS37071.1
    UniProtKB/Swiss-Prot
    Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BHS8, Q8BI27
    Related
    ENSMUSP00000105896.2, ENSMUST00000110267.9
    Conserved Domains (1) summary
    pfam15290
    Location:239 → 429
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    44535252..44651466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521067.4 → XP_006521130.3  syntabulin isoform X2

    Conserved Domains (1) summary
    pfam15290
    Location:350 → 631
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  2. XM_017316662.2 → XP_017172151.1  syntabulin isoform X1

    Conserved Domains (1) summary
    pfam15290
    Location:351 → 632
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  3. XM_017316665.1 → XP_017172154.1  syntabulin isoform X9

    Conserved Domains (1) summary
    pfam15290
    Location:151 → 432
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  4. XM_036159461.1 → XP_036015354.1  syntabulin isoform X8

    Conserved Domains (1) summary
    pfam15290
    Location:173 → 468
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  5. XM_017316664.1 → XP_017172153.1  syntabulin isoform X7

    Conserved Domains (1) summary
    pfam15290
    Location:181 → 462
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  6. XM_036159463.1 → XP_036015356.1  syntabulin isoform X12

    Conserved Domains (1) summary
    pfam15290
    Location:5 → 300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  7. XM_036159460.1 → XP_036015353.1  syntabulin isoform X6

    Conserved Domains (1) summary
    pfam15290
    Location:221 → 516
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  8. XM_036159459.1 → XP_036015352.1  syntabulin isoform X5

    Conserved Domains (1) summary
    pfam15290
    Location:222 → 517
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  9. XM_036159458.1 → XP_036015351.1  syntabulin isoform X4

    Conserved Domains (1) summary
    pfam15290
    Location:274 → 569
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  10. XM_036159465.1 → XP_036015358.1  syntabulin isoform X12

    Conserved Domains (1) summary
    pfam15290
    Location:5 → 300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  11. XM_036159462.1 → XP_036015355.1  syntabulin isoform X10

    Conserved Domains (1) summary
    pfam15290
    Location:99 → 394
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp

  12. XM_036159464.1 → XP_036015357.1  syntabulin isoform X12

    Conserved Domains (1) summary
    pfam15290
    Location:5 → 300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHS8.1 GenPept UniProtKB/Swiss-Prot:Q8BHS8

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