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Syt15 synaptotagmin XV [ Mus musculus (house mouse) ]

Gene ID: 319508, updated on 11-Apr-2024

Summary

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Official Symbol
Syt15provided by MGI
Official Full Name
synaptotagmin XVprovided by MGI
Primary source
MGI:MGI:2442166
See related
Ensembl:ENSMUSG00000041479 AllianceGenome:MGI:2442166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sytXV; CHR10SYT; E230025K04Rik
Summary
Predicted to enable several functions, including SNARE binding activity; calcium ion binding activity; and phospholipid binding activity. Predicted to be involved in calcium-ion regulated exocytosis; cellular response to calcium ion; and regulation of secretion by cell. Is extrinsic component of membrane. Is expressed in several structures, including brain; heart; lung; skeletal muscle; and testis. Orthologous to human SYT15 (synaptotagmin 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 3.8), ovary adult (RPKM 3.7) and 25 other tissues See more
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Genomic context

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See Syt15 in Genome Data Viewer
Location:
14 B; 14 20.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33941915..33952378)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34219956..34230421)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36364 Neighboring gene VISTA enhancer mm340 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene shieldin complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_36366 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36368 Neighboring gene STARR-seq mESC enhancer starr_36370 Neighboring gene STARR-seq mESC enhancer starr_36372 Neighboring gene STARR-seq mESC enhancer starr_36373 Neighboring gene glutamate dehydrogenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis. Ishihara Y, et al. Toxicol Lett, 2003 Apr 30. PMID 12765241
  2. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. Fukuda M. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788067
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular cloning and structure
    Title: Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176931.2 → NP_795905.2  synaptotagmin-15 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) uses a different segment for its 3' coding region and UTR, compared to variant a. The resulting protein (isoform b) has a shorter and distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    AK042641, BC139314
    Consensus CDS
    CCDS49444.1
    UniProtKB/Swiss-Prot
    Q8C6N3
    Related
    ENSMUSP00000113725.2, ENSMUST00000119693.8
    Conserved Domains (2) summary
    cd08390
    Location:146 → 266
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:276 → 370
    C2; C2 domain

  2. NM_181529.4 → NP_852682.1  synaptotagmin-15 isoform a

    See identical proteins and their annotated locations for NP_852682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC154738, BB639494, BC139314
    Consensus CDS
    CCDS26934.1
    UniProtKB/Swiss-Prot
    B2RTF1, Q7TN81, Q7TN82, Q8C6N3, Q8C999
    Related
    ENSMUSP00000036755.6, ENSMUST00000035351.7
    Conserved Domains (2) summary
    cd08390
    Location:146 → 266
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:276 → 413
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33941915..33952378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316056.3 → XP_017171545.1  synaptotagmin-15 isoform X1

    Conserved Domains (2) summary
    cd08390
    Location:139 → 259
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cl14603
    Location:269 → 406
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6N3.1 GenPept UniProtKB/Swiss-Prot:Q8C6N3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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