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Tpt tRNA 2'-phosphotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318833, updated on 4-Apr-2024

Summary

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Official Symbol
Tptprovided by FlyBase
Official Full Name
tRNA 2'-phosphotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0053057
Locus tag
Dmel_CG33057
See related
AllianceGenome:FB:FBgn0053057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33057; Dmel\CG33057; Tpt1
Summary
Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Orthologous to human TRPT1 (tRNA phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
66C11-66C11; 3-24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8402168..8405277, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8395268..8398377, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 66Ci Neighboring gene Jonah 66Cii Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene uncharacterized protein Neighboring gene Outer segment 1 Neighboring gene Exocyst 70 Neighboring gene matrimony

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allele-specific alternative splicing of Drosophila Ribosomal protein S21 suppresses a lethal mutation in the Phosphorylated adaptor for RNA export (Phax) gene. Garcia EL. G3 (Bethesda), 2022 Aug 25. PMID 35920767, Free PMC Article
  2. Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia. Schmidt CA, et al. Biol Open, 2022 Mar 15. PMID 35132432, Free PMC Article
  3. Molecular determinants of metazoan tricRNA biogenesis. Schmidt CA, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31032518, Free PMC Article
  4. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article
  5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA 2'-phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA 2'-phosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA splicing, via endonucleolytic cleavage and ligation ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tRNA 2'-phosphotransferase
Names
CG33057-PA
CG33057-PB
Tpt-PA
Tpt-PB
NP_001286980.1
NP_788477.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8402168..8405277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300051.1 → NP_001286980.1  tRNA 2'-phosphotransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286980.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BH3
    Conserved Domains (1) summary
    pfam01885
    Location:11 → 183
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

  2. NM_176299.3 → NP_788477.1  tRNA 2'-phosphotransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788477.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BH3
    Related
    FBpp0076401
    Conserved Domains (1) summary
    pfam01885
    Location:11 → 183
    PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BH3 Q86BH3

Gene LinkOut

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