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Adamtsl4 ADAMTS-like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310670, updated on 3-Apr-2024

Summary

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Official Symbol
Adamtsl4provided by RGD
Official Full Name
ADAMTS-like 4provided by RGD
Primary source
RGD:1561012
See related
Ensembl:ENSRNOG00000049385 AllianceGenome:RGD:1561012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsrc1
Summary
Predicted to enable identical protein binding activity and protease binding activity. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within epithelial cell development and extracellular matrix organization. Predicted to be located in interstitial matrix. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 111.6), Muscle (RPKM 100.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adamtsl4 in Genome Data Viewer
Location:
2q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185924582..185936039, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183235634..183247091, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197803572..197815058, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene endosulfine alpha Neighboring gene MCL1 apoptosis regulator, BCL2 family member Neighboring gene uncharacterized LOC120100878 Neighboring gene uncharacterized LOC120100879 Neighboring gene extracellular matrix protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. Liu J, et al. FEBS Lett, 2006 Jan 9. PMID 16364318
  2. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article
  3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116260

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epithelial cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigment cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in interstitial matrix ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 4
Names
ADAMTSL-4
thrombospondin repeat protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034012.1 → NP_001029184.1  ADAMTS-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001029184.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099119
    UniProtKB/Swiss-Prot
    Q4FZU4
    Related
    ENSRNOP00000063998.1, ENSRNOT00000074156.2
    Conserved Domains (3) summary
    smart00209
    Location:46 → 75
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:446 → 559
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:989 → 1018
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185924582..185936039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590903.2 → XP_017446392.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4
    Conserved Domains (3) summary
    smart00209
    Location:46 → 75
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:446 → 559
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:989 → 1018
    PLAC; PLAC (protease and lacunin) domain

  2. XM_039102360.1 → XP_038958288.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_039102358.1 → XP_038958286.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_063281876.1 → XP_063137946.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4

  5. XM_039102363.1 → XP_038958291.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  6. XM_017590906.3 → XP_017446395.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4
    Conserved Domains (3) summary
    smart00209
    Location:46 → 75
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:446 → 559
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:989 → 1018
    PLAC; PLAC (protease and lacunin) domain

  7. XM_039102362.2 → XP_038958290.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  8. XM_063281874.1 → XP_063137944.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4

  9. XM_039102361.1 → XP_038958289.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  10. XM_063281878.1 → XP_063137948.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4

  11. XM_039102359.2 → XP_038958287.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  12. XM_063281875.1 → XP_063137945.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4

  13. XM_039102364.2 → XP_038958292.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:994 → 1023
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  14. XM_017590907.3 → XP_017446396.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4
    Conserved Domains (3) summary
    smart00209
    Location:46 → 75
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:446 → 559
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:989 → 1018
    PLAC; PLAC (protease and lacunin) domain

  15. XM_063281877.1 → XP_063137947.1  ADAMTS-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4FZU4

  16. XM_039102367.2 → XP_038958295.1  ADAMTS-like protein 4 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:690 → 746
    TSP1_ADAMTS; Thrombospondin type 1 domain

  17. XM_039102366.2 → XP_038958294.1  ADAMTS-like protein 4 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:24 → 358
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:451 → 564
    ADAM_spacer1; ADAM-TS Spacer 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZU4.1 GenPept UniProtKB/Swiss-Prot:Q4FZU4

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