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Prss30 serine protease 30 [ Mus musculus (house mouse) ]

Gene ID: 30943, updated on 8-Feb-2024

Summary

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Official Symbol
Prss30provided by MGI
Official Full Name
serine protease 30provided by MGI
Primary source
MGI:MGI:1353645
See related
Ensembl:ENSMUSG00000024124 AllianceGenome:MGI:1353645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Disp; Disp1; Tmprss8; 2010015P21Rik
Summary
Predicted to enable serine-type endopeptidase activity and sodium channel regulator activity. Predicted to be involved in proteolysis and sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in extracellular space. Is expressed in embryo; prostate gland; and smooth muscle tissue. Orthologous to human PRSS30P (serine protease 30, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 83.0), large intestine adult (RPKM 60.3) and 2 other tissues See more
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Genomic context

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Location:
17 12.17 cM; 17 A3.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24191100..24199545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23972126..23980571, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41545 Neighboring gene spermine binding protein Neighboring gene spermine binding protein-like Neighboring gene predicted gene, 41546 Neighboring gene serine protease 22 Neighboring gene predicted gene, 41547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith CJ, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786627
  2. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease 30
Names
distal intestinal serine protease
protease, serine 30
transmembrane protease, serine 8 (intestinal)
transmembrane serine protease 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013921.3 → NP_038949.2  serine protease 30 precursor

    See identical proteins and their annotated locations for NP_038949.2

    Status: VALIDATED

    Source sequence(s)
    AC110262
    Consensus CDS
    CCDS28470.1
    UniProtKB/Swiss-Prot
    Q91XC4, Q9QYZ9
    Related
    ENSMUSP00000024936.4, ENSMUST00000024936.11
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24191100..24199545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524382.4 → XP_006524445.1  serine protease 30 isoform X3

    See identical proteins and their annotated locations for XP_006524445.1

    UniProtKB/Swiss-Prot
    Q91XC4, Q9QYZ9
    Related
    ENSMUSP00000157077.2, ENSMUST00000234765.2
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_011246484.2 → XP_011244786.1  serine protease 30 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:74 → 296
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_011246483.2 → XP_011244785.1  serine protease 30 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:74 → 312
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_011246485.1 → XP_011244787.1  serine protease 30 isoform X4

    UniProtKB/TrEMBL
    D6REI2
    Related
    ENSMUSP00000117647.2, ENSMUST00000151448.8
    Conserved Domains (1) summary
    cd00190
    Location:74 → 213
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYZ9.2 GenPept UniProtKB/Swiss-Prot:Q9QYZ9

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