myh7 myosin heavy chain 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myh7provided by ZNC
Official Full Name: myosin heavy chain 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-991123-5
See related: Ensembl:ENSDARG00000079564 AllianceGenome:ZFIN:ZDB-GENE-991123-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vmhc; smyhc3; mg:cb02g011
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within embryonic heart tube development and ventricular cardiac myofibril assembly. Predicted to be part of myosin complex. Is expressed in several structures, including heart primordium; heart rudiment; mesoderm; musculature system; and pericardial region. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (24256521..24269913, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (24600870..24614262, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prrx1b, a Prx-related homeobox protein, participates in the regulation of vmhc expression with other transcriptional factors.
Title: Promoter analysis of ventricular myosin heavy chain (vmhc) in zebrafish embryos.
Data suggest that ventricle-specific expression of myosin heavy chain is achieved through an inhibitory mechanism that suppresses expression in the atrium.
Title: Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
Title: Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac ventricle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IEP Inferred from Expression Pattern more info
involved_in muscle filament sliding	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin-7

Names: ventricular myosin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112733.1 → NP_001106204.1 myosin-7

Status: PROVISIONAL

Source sequence(s)

BX000358

UniProtKB/TrEMBL

A0A8M1NF11, F1QZW1

Related

ENSDARP00000090306.4, ENSDART00000099532.5

Conserved Domains (10) summary

cd01377
Location:99 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:87 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:848 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 72

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1742 → 1832

TMPIT; TMPIT-like protein

cd16269
Location:1795 → 1805

GBP_C; coiled coil [structural motif]

cl00459
Location:780 → 991

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl19764
Location:1374 → 1536

COG6; Conserved oligomeric complex COG6

cl20817
Location:1563 → 1825

GBP_C; Guanylate-binding protein, C-terminal domain

cl23720
Location:963 → 1096

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)