Hdgfl3 HDGF like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdgfl3provided by MGI
Official Full Name: HDGF like 3provided by MGI
Primary source: MGI:MGI:1352760
See related: Ensembl:ENSMUSG00000025104 AllianceGenome:MGI:1352760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRP-3; Hdgfrp3; 2700022B06Rik
Summary: Enables microtubule binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in cytosol and nucleus. Is expressed in metanephros and nervous system. Orthologous to human HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 20.4), whole brain E14.5 (RPKM 19.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (81531004..81587227, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81881256..81934459, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
Title: Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.
Antibody-mediated neutralization of HRP-3 function results in neuronal degeneration; this protein also exerts a neurite outgrowth-promoting effect when it is presented as a coated substrate but not as a soluble factor.
Title: Hepatoma-derived growth factor-related protein-3: a new neurotrophic and neurite outgrowth-promoting factor for cortical neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	NAS Non-traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: hepatoma-derived growth factor-related protein 3

Names: hepatoma-derived growth factor, related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013886.4 → NP_038914.2 hepatoma-derived growth factor-related protein 3

See identical proteins and their annotated locations for NP_038914.2

Status: VALIDATED

Source sequence(s)

AK012267, AK045542, AK162418

Consensus CDS

CCDS40011.1

UniProtKB/Swiss-Prot

Q3TRX2, Q8BQ69, Q8BR62, Q9D2M7, Q9JMG7

Related

ENSMUSP00000102926.2, ENSMUST00000107305.8

Conserved Domains (1) summary

cd05834
Location:7 → 91

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

81531004..81587227 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153161.1 → XP_036009054.1 hepatoma-derived growth factor-related protein 3 isoform X1

UniProtKB/TrEMBL

Q3TR90

Conserved Domains (1) summary

cd05834
Location:7 → 91

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...