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Cabp5 calcium binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 29865, updated on 21-Apr-2024

Summary

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Official Symbol
Cabp5provided by MGI
Official Full Name
calcium binding protein 5provided by MGI
Primary source
MGI:MGI:1352746
See related
Ensembl:ENSMUSG00000005649 AllianceGenome:MGI:1352746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium ion binding activity. Predicted to be located in cytosol. Is expressed in ovary; stomach; and testis. Orthologous to human CABP5 (calcium binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 7.87 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13119885..13142812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13385960..13408887)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene Neighboring gene STARR-seq mESC enhancer starr_18079 Neighboring gene ribosomal protein L7A, pseudogene 14 Neighboring gene binder of sperm protein homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of Ca2+-binding protein 5 knockout mouse retina. Rieke F, et al. Invest Ophthalmol Vis Sci, 2008 Nov. PMID 18586882, Free PMC Article
  2. Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis. Sokal I, et al. Invest Ophthalmol Vis Sci, 2011 Nov 25. PMID 22039235, Free PMC Article
  3. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Sokal I, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11108966
  4. The transcription factor Bhlhb4 is required for rod bipolar cell maturation. Bramblett DE, et al. Neuron, 2004 Sep 16. PMID 15363390
  5. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. Haeseleer F, et al. J Biol Chem, 2000 Jan 14. PMID 10625670, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418438.1 → NP_001405367.1  calcium-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156985

  2. NM_001418448.1 → NP_001405377.1  calcium-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156985
    UniProtKB/TrEMBL
    D3YWT5
    Related
    ENSMUSP00000112415.2, ENSMUST00000117400.2

  3. NM_013877.4 → NP_038905.1  calcium-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_038905.1

    Status: VALIDATED

    Source sequence(s)
    AC156985
    Consensus CDS
    CCDS20831.1
    UniProtKB/Swiss-Prot
    Q9JLK3
    UniProtKB/TrEMBL
    Q543X4
    Related
    ENSMUSP00000005791.8, ENSMUST00000005791.14
    Conserved Domains (2) summary
    PTZ00184
    Location:25 → 171
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:109 → 172
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. NR_184745.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  2. NR_184746.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  3. NR_184747.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  4. NR_184748.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  5. NR_184749.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  6. NR_184750.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

  7. NR_184751.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156985

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    13119885..13142812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322297.1 → XP_017177786.1  calcium-binding protein 5 isoform X1

    Conserved Domains (1) summary
    PTZ00184
    Location:8 → 154
    PTZ00184; calmodulin; Provisional

  2. XM_017322298.2 → XP_017177787.1  calcium-binding protein 5 isoform X1

    Conserved Domains (1) summary
    PTZ00184
    Location:8 → 154
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLK3.1 GenPept UniProtKB/Swiss-Prot:Q9JLK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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