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SENP1 SUMO specific peptidase 1 [ Homo sapiens (human) ]

Gene ID: 29843, updated on 7-Apr-2024

Summary

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Official Symbol
SENP1provided by HGNC
Official Full Name
SUMO specific peptidase 1provided by HGNC
Primary source
HGNC:HGNC:17927
See related
Ensembl:ENSG00000079387 MIM:612157; AllianceGenome:HGNC:17927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SuPr-2
Summary
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
12q13.11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48042897..48106079, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48004645..48067418, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48436680..48499862, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48375074-48375619 Neighboring gene collagen type II alpha 1 chain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404129-48404630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404631-48405130 Neighboring gene uncharacterized LOC105369750 Neighboring gene uncharacterized LOC124902927 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:48415301-48416292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48431351-48432291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:48439137-48440336 Neighboring gene ribosomal protein L37 pseudogene 19 Neighboring gene V-type proton ATPase subunit F-like Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:48484832-48485048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48498859-48499734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48499735-48500608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6279 Neighboring gene phosphofructokinase, muscle Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48536214-48537195 Neighboring gene microRNA 6505 Neighboring gene NANOG hESC enhancer GRCh37_chr12:48551082-48551604 Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [SENP1 induced protein deSUMO modification increased the chemotherapy sensitivity of endometrial cancer side population cells]. Yuan ML, et al. Zhonghua Zhong Liu Za Zhi, 2022 Dec 23. PMID 36575788
  2. SENP1 participates in Irinotecan resistance in human colon cancer cells. Chen MC, et al. J Cell Biochem, 2021 Oct. PMID 34037277
  3. SENP1 is required for the growth, migration, and survival of human adipose-derived stem cells. Wu Y, et al. Adipocyte, 2021 Dec. PMID 33371766, Free PMC Article
  4. SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance. Varone E, et al. Redox Biol, 2019 Jun. PMID 30921636, Free PMC Article
  5. SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Sun XX, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30305424, Free PMC Article

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
    Title: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
  2. EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signallingdagger.
    Title: EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†.
  3. SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
    Title: SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
  4. A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding.
    Title: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
  5. SENP1-mediated SUMOylation of SIRT1 affects glioma development through the NF-kappaB pathway.
    Title: SENP1-mediated SUMOylation of SIRT1 affects glioma development through the NF-κB pathway.
  6. SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.
    Title: SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.
  7. MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape.
    Title: MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape.
  8. SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.
    Title: SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.
  9. LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1alpha axis.
    Title: LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis.
  10. SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization.
    Title: SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO-specific endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sentrin-specific protease 1
Names
SUMO1/sentrin specific peptidase 1
SUMO1/sentrin specific protease 1
sentrin/SUMO-specific protease SENP1
NP_001254523.1
NP_001254524.1
XP_006719424.1
XP_011536546.1
XP_011536547.1
XP_016874718.1
XP_016874719.1
XP_016874720.1
XP_016874721.1
XP_016874722.1
XP_016874723.1
XP_016874724.1
XP_016874726.1
XP_047284708.1
XP_054227853.1
XP_054227854.1
XP_054227855.1
XP_054227856.1
XP_054227857.1
XP_054227858.1
XP_054227859.1
XP_054227860.1
XP_054227861.1
XP_054227862.1
XP_054227863.1
XP_054227864.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267594.2 → NP_001254523.1  sentrin-specific protease 1

    See identical proteins and their annotated locations for NP_001254523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004801, AK312874, BX640784
    Consensus CDS
    CCDS44868.2
    UniProtKB/Swiss-Prot
    A8K7P5, Q86XC8, Q9P0U3
    Related
    ENSP00000447328.1, ENST00000549518.6
    Conserved Domains (1) summary
    cl23802
    Location:420 → 642
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_001267595.2 → NP_001254524.1  sentrin-specific protease 1

    See identical proteins and their annotated locations for NP_001254524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004801, BC045639, BX537920, BX640784
    Consensus CDS
    CCDS44868.2
    UniProtKB/Swiss-Prot
    A8K7P5, Q86XC8, Q9P0U3
    Related
    ENSP00000394791.2, ENST00000448372.6
    Conserved Domains (1) summary
    cl23802
    Location:420 → 642
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

  1. NR_051991.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004801, BX537920, BX640784
    Related
    ENST00000552189.5

  2. NR_051992.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004801, BX537920, BX640784

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48042897..48106079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019237.2 → XP_016874726.1  sentrin-specific protease 1 isoform X9

  2. XM_017019235.2 → XP_016874724.1  sentrin-specific protease 1 isoform X8

  3. XM_017019232.2 → XP_016874721.1  sentrin-specific protease 1 isoform X4

  4. XM_047428752.1 → XP_047284708.1  sentrin-specific protease 1 isoform X7

  5. XM_011538245.4 → XP_011536547.1  sentrin-specific protease 1 isoform X6

    Conserved Domains (1) summary
    cl23802
    Location:436 → 658
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  6. XM_011538244.4 → XP_011536546.1  sentrin-specific protease 1 isoform X5

    Conserved Domains (1) summary
    cl23802
    Location:439 → 661
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  7. XM_006719361.4 → XP_006719424.1  sentrin-specific protease 1 isoform X3

    See identical proteins and their annotated locations for XP_006719424.1

    Conserved Domains (1) summary
    cl23802
    Location:452 → 674
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  8. XM_017019233.3 → XP_016874722.1  sentrin-specific protease 1 isoform X8

  9. XM_017019230.3 → XP_016874719.1  sentrin-specific protease 1 isoform X2

  10. XM_017019229.3 → XP_016874718.1  sentrin-specific protease 1 isoform X1

  11. XM_017019234.3 → XP_016874723.1  sentrin-specific protease 1 isoform X8

  12. XM_017019231.3 → XP_016874720.1  sentrin-specific protease 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48004645..48067418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371889.1 → XP_054227864.1  sentrin-specific protease 1 isoform X9

  2. XM_054371887.1 → XP_054227862.1  sentrin-specific protease 1 isoform X8

  3. XM_054371881.1 → XP_054227856.1  sentrin-specific protease 1 isoform X4

  4. XM_054371885.1 → XP_054227860.1  sentrin-specific protease 1 isoform X7

  5. XM_054371884.1 → XP_054227859.1  sentrin-specific protease 1 isoform X6

  6. XM_054371883.1 → XP_054227858.1  sentrin-specific protease 1 isoform X5

  7. XM_054371880.1 → XP_054227855.1  sentrin-specific protease 1 isoform X3

  8. XM_054371888.1 → XP_054227863.1  sentrin-specific protease 1 isoform X8

  9. XM_054371879.1 → XP_054227854.1  sentrin-specific protease 1 isoform X2

  10. XM_054371878.1 → XP_054227853.1  sentrin-specific protease 1 isoform X1

  11. XM_054371886.1 → XP_054227861.1  sentrin-specific protease 1 isoform X8

  12. XM_054371882.1 → XP_054227857.1  sentrin-specific protease 1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014554.2: Suppressed sequence

    Description
    NM_014554.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P0U3.2 GenPept UniProtKB/Swiss-Prot:Q9P0U3

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