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Acy3 aminoacylase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293653, updated on 3-Apr-2024

Summary

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Official Symbol
Acy3provided by RGD
Official Full Name
aminoacylase 3provided by RGD
Primary source
RGD:1305394
See related
Ensembl:ENSRNOG00000017901 AllianceGenome:RGD:1305394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305394
Summary
Predicted to enable aminoacylase activity and identical protein binding activity. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in cytosol. Orthologous to human ACY3 (aminoacylase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1045.5), Liver (RPKM 89.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210709238..210715258)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201279751..201285803)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219233712..219237103)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene T-box transcription factor 10 Neighboring gene nudix hydrolase 8 Neighboring gene double C2-like domains, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Tsirulnikov K, et al. Toxicol Appl Pharmacol, 2012 Sep 15. PMID 22819785, Free PMC Article
  2. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. Tsirulnikov K, et al. FEBS Lett, 2012 Nov 2. PMID 23010594, Free PMC Article
  3. Structures of aminoacylase 3 in complex with acetylated substrates. Hsieh JM, et al. Proc Natl Acad Sci U S A, 2010 Oct 19. PMID 20921362, Free PMC Article
  4. Structural characterization of dimeric murine aminoacylase III. Ryazantsev S, et al. FEBS Lett, 2007 May 1. PMID 17434493
  5. Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. Pushkin A, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14656720

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we report a new potential mechanism for neuronal damage in Alzheimer disease that involves AA3; This previously unrecognized mechanism may also function in Parkinson disease
    Title: Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108859

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Names
ACY-3
aspartoacylase (aminoacylase) 3
aspartoacylase (aminocyclase) 3
aspartoacylase 3
aspartoacylase-2
NP_001009603.1
XP_006230796.1
XP_038964147.1
XP_038964150.1
XP_038964154.1
XP_038964157.1
XP_038964162.1
XP_063142835.1
XP_063142839.1
XP_063142846.1
XP_063142852.1
XP_063142854.1
XP_063142862.1
XP_063142863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009603.1 → NP_001009603.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

    See identical proteins and their annotated locations for NP_001009603.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088190
    UniProtKB/Swiss-Prot
    Q5M876
    UniProtKB/TrEMBL
    A6HYP7
    Related
    ENSRNOP00000024112.4, ENSRNOT00000024112.7
    Conserved Domains (1) summary
    cl11393
    Location:13 → 303
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210709238..210715258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108219.2 → XP_038964147.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    Conserved Domains (1) summary
    cd06909
    Location:13 → 206
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

  2. XM_039108234.2 → XP_038964162.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

    Conserved Domains (1) summary
    cd06909
    Location:13 → 196
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

  3. XM_006230734.4 → XP_006230796.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X5

    Conserved Domains (2) summary
    pfam04952
    Location:10 → 244
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
    cl11393
    Location:13 → 249
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  4. XM_063286782.1 → XP_063142852.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X4

  5. XM_039108229.2 → XP_038964157.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    Conserved Domains (1) summary
    cd06909
    Location:13 → 206
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

  6. XM_063286792.1 → XP_063142862.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X5

  7. XM_063286776.1 → XP_063142846.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

    UniProtKB/Swiss-Prot
    Q5M876
    UniProtKB/TrEMBL
    A6HYP7

  8. XM_063286784.1 → XP_063142854.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X4

  9. XM_063286769.1 → XP_063142839.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

    UniProtKB/Swiss-Prot
    Q5M876
    UniProtKB/TrEMBL
    A6HYP7

  10. XM_039108226.2 → XP_038964154.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    Conserved Domains (1) summary
    cd06909
    Location:13 → 206
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

  11. XM_063286793.1 → XP_063142863.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X6

  12. XM_063286765.1 → XP_063142835.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

  13. XM_039108222.2 → XP_038964150.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

    Conserved Domains (1) summary
    cd06909
    Location:13 → 206
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M876.1 GenPept UniProtKB/Swiss-Prot:Q5M876

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