Alkbh4 alkB homolog 4, lysine demethylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alkbh4provided by RGD
Official Full Name: alkB homolog 4, lysine demethylaseprovided by RGD
Primary source: RGD:1308608
See related: Ensembl:ENSRNOG00000001428 AllianceGenome:RGD:1308608
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308608
Summary: Predicted to enable actin binding activity and oxidative DNA demethylase activity. Predicted to be involved in several processes, including DNA demethylation; cleavage furrow ingression; and protein demethylation. Predicted to be active in contractile ring and midbody. Orthologous to human ALKBH4 (alkB homolog 4, lysine demethylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 54.9), Spleen (RPKM 29.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26160643..26166560, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20524030..20529947, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23568204..23574133, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables broad specificity oxidative DNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow ingression	ISO Inferred from Sequence Orthology more info
involved_in demethylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in protein demethylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in contractile ring	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Names: alkB homolog 4, lysine demthylase; alkB, alkylation repair homolog 4; alkylated DNA repair protein alkB homolog 4

NP_001099390.1

EC 1.14.11.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.