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mcm5 minichromosome maintenance complex component 5 [ Danio rerio (zebrafish) ]

Gene ID: 286747, updated on 27-Mar-2024

Summary

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Official Symbol
mcm5provided by ZNC
Official Full Name
minichromosome maintenance complex component 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-021209-1
See related
Ensembl:ENSDARG00000019507 AllianceGenome:ZFIN:ZDB-GENE-021209-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb34a06
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Acts upstream of or within chordate embryonic development; mitotic cell cycle; and negative regulation of apoptotic process. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mcm5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25999477..26011440)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25868606..25880569)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885347 Neighboring gene glycine C-acetyltransferase Neighboring gene heme oxygenase 1a Neighboring gene FAD-dependent oxidoreductase domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Large-scale live imaging of adult neural stem cells in their endogenous niche. Dray N, et al. Development, 2015 Oct 15. PMID 26395477, Free PMC Article
  2. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358633
  3. Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon. März M, et al. Glia, 2010 May. PMID 20155821
  4. Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis. Ryu S, et al. Cell Cycle, 2006 Jun. PMID 16721065
  5. Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling. Wu Y, et al. Dev Neurosci, 2021. PMID 34130286

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. different tissues may employ distinct cellular programs in responding to the depletion of MCM5
    Title: Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration in hindbrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell proliferation in hindbrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM5
Names
MCM5 minichromosome maintenance deficient 5
NP_848523.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178436.3 → NP_848523.2  DNA replication licensing factor MCM5

    See identical proteins and their annotated locations for NP_848523.2

    Status: PROVISIONAL

    Source sequence(s)
    BC068359
    UniProtKB/TrEMBL
    Q6NV07
    Related
    ENSDARP00000018877.8, ENSDART00000024316.9
    Conserved Domains (3) summary
    cd00009
    Location:378 → 522
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00350
    Location:134 → 651
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:35 → 154
    MCM_N; MCM N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    25999477..26011440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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