ADRB3 adrenoceptor beta 3 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADRB3provided by VGNC
Official Full Name: adrenoceptor beta 3provided by VGNC
Primary source: VGNC:VGNC:25698
See related: BGD:BT10229; Ensembl:ENSBTAG00000017981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (33208459..33211323, complement)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation in the promoter region of bovine ADRB3 was investigated.
Title: Polymorphism of the bovine ADRB3 gene.
small G protein Rac1 is a key regulator of beta(3)AR signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS pathways in the vascular wall
Title: Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling.
of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)
Title: Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows.
beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance
Title: Ontogenetic development of mRNA levels and binding sites of hepatic beta-adrenergic receptors in cattle.

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General gene information

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Markers

ADRB3 (e-PCR)
- UniSTS:506234

PMC164531P1 (e-PCR)
- UniSTS:271495

MARC_68773-68774:1209743884:2 (e-PCR)
- UniSTS:528345

X85961 (e-PCR)
- UniSTS:279266

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta3-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables epinephrine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables norepinephrine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-3 adrenergic receptor

Names: adrenergic, beta 3, receptor; adrenergic, beta-3-, receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174232.2 → NP_776657.1 beta-3 adrenergic receptor

See identical proteins and their annotated locations for NP_776657.1

Status: PROVISIONAL

Source sequence(s)

X85961

UniProtKB/Swiss-Prot

P46626, Q1LZC1, Q28045, Q9TS17

UniProtKB/TrEMBL

A0A452DJP2

Related

ENSBTAP00000023923.4, ENSBTAT00000023923.5

Conserved Domains (2) summary

pfam00001
Location:54 → 346

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 145

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

Range

33208459..33211323 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005226092.5 → XP_005226149.1 beta-3 adrenergic receptor isoform X1

UniProtKB/TrEMBL

A0A3Q1MQZ8, A0A452DJP2

Related

ENSBTAP00000074082.1, ENSBTAT00000085511.2

Conserved Domains (2) summary

pfam00001
Location:79 → 371

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:79 → 170

7tm_4; Olfactory receptor