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ABCC1 ATP binding cassette subfamily C member 1 [ Bos taurus (cattle) ]

Gene ID: 281588, updated on 5-Mar-2024

Summary

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Official Symbol
ABCC1provided by VGNC
Official Full Name
ATP binding cassette subfamily C member 1provided by VGNC
Primary source
VGNC:VGNC:25468
See related
BGD:BT20340; Ensembl:ENSBTAG00000021090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (14330154..14482212)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene rho-related GTP-binding protein RhoA-B-like Neighboring gene centrosomal protein 20 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene uncharacterized LOC112444306 Neighboring gene BOS complex subunit NOMO1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1. Johnson ZL, et al. Cell, 2017 Mar 9. PMID 28238471
  2. Functional analysis of MRP1 cloned from bovine. Taguchi Y, et al. FEBS Lett, 2002 Jun 19. PMID 12067707
  3. Study on functional sites in human multidrug resistance protein 1 (hMRP1). He J, et al. Proteins, 2021 Jun. PMID 33469960
  4. An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. Helms HC, et al. AAPS J, 2014 Sep. PMID 24934296, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study on functional sites in human multidrug resistance protein 1 (hMRP1).
    Title: Study on functional sites in human multidrug resistance protein 1 (hMRP1).
  2. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.
    Title: Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
  3. P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
    Title: An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
LTC4 transporter
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
NP_776648.1
XP_024840415.1
XP_024840416.1
XP_024840417.1
XP_024840420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174223.1 → NP_776648.1  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_776648.1

    Status: PROVISIONAL

    Source sequence(s)
    AB082124
    UniProtKB/Swiss-Prot
    Q8HXQ5
    UniProtKB/TrEMBL
    A0A3Q1LMX5
    Related
    ENSBTAP00000028094.6, ENSBTAT00000028094.6
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1529
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    14330154..14482212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024984647.2 → XP_024840415.1  multidrug resistance-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LMX5
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. XM_024984648.2 → XP_024840416.1  multidrug resistance-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LMX5
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1529
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  3. XM_024984649.2 → XP_024840417.1  multidrug resistance-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LMX5
    Conserved Domains (1) summary
    TIGR00957
    Location:7 → 1528
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  4. XM_024984652.2 → XP_024840420.1  multidrug resistance-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LMX5
    Conserved Domains (1) summary
    cl26602
    Location:6 → 1338
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HXQ5.1 GenPept UniProtKB/Swiss-Prot:Q8HXQ5

Gene LinkOut

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