Adam1b a disintegrin and metallopeptidase domain 1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam1bprovided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 1bprovided by MGI
Primary source: MGI:MGI:2429506
See related: Ensembl:ENSMUSG00000062438 AllianceGenome:MGI:2429506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ftna; Adam1
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in binding activity of sperm to zona pellucida and male gonad development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADAM1B (ADAM metallopeptidase domain 1B (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5 F; 5 61.83 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (121638159..121641498, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (121500096..121503435, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
Title: Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
These results suggest that mouse ADAM1b/ADAM2 fertilin may play a crucial role not in the sperm/egg fusion but in the appearance of these two ADAMs on the sperm surface.
Title: Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U22056 (e-PCR)
- UniSTS:125697

AW050088 (e-PCR)
- UniSTS:179254

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	NAS Non-traceable Author Statement more info	PubMed
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 1b

Names: PH-30 alpha; a disintegrin and metalloproteinase domain 1b; fertilin alpha; fertilin subunit alpha-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172125.3 → NP_742123.2 disintegrin and metalloproteinase domain-containing protein 1b precursor

See identical proteins and their annotated locations for NP_742123.2

Status: VALIDATED

Source sequence(s)

AC129215, AK016558, BB679367, BC140979

Consensus CDS

CCDS19636.1

UniProtKB/Swiss-Prot

B2RU57, Q8R534, Q9R156

Related

ENSMUSP00000078343.4, ENSMUST00000079368.5

Conserved Domains (5) summary

smart00608
Location:489 → 625

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:203 → 395

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:415 → 485

Disintegrin; Disintegrin

pfam01421
Location:203 → 397

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:63 → 158

Pep_M12B_propep; Reprolysin family propeptide