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GOLGA3 golgin A3 [ Homo sapiens (human) ]

Gene ID: 2802, updated on 7-Apr-2024

Summary

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Official Symbol
GOLGA3provided by HGNC
Official Full Name
golgin A3provided by HGNC
Primary source
HGNC:HGNC:4426
See related
Ensembl:ENSG00000090615 MIM:602581; AllianceGenome:HGNC:4426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA-2; GCP170
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in colon (RPKM 8.3), brain (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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See GOLGA3 in Genome Data Viewer
Location:
12q24.33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132768914..132829081, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132819976..132879866, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133345500..133405667, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 379 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene TPD52 like 2 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133334029-133334208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133337764-133338632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7389 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133365291-133365792 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5130 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:133412143-133413342 Neighboring gene ribosomal protein S11 pseudogene 5 Neighboring gene RNA, U6 small nuclear 327, pseudogene Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133428785-133429286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133429287-133429786 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:133433141-133434340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133449077-133449774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133449775-133450470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133450471-133451166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133451167-133451862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7393 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133464984-133465786 Neighboring gene CHFR divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Three basic residues of intracellular loop 3 of the beta-1 adrenergic receptor are required for golgin-160-dependent trafficking. Gilbert CE, et al. Int J Mol Sci, 2014 Feb 20. PMID 24566136, Free PMC Article
  2. Golgin160 recruits the dynein motor to position the Golgi apparatus. Yadav S, et al. Dev Cell, 2012 Jul 17. PMID 22814606, Free PMC Article
  3. Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes. Fierabracci A, et al. Diabetes Res Clin Pract, 2010 May. PMID 20170975
  4. Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. Maag RS, et al. Mol Biol Cell, 2005 Jun. PMID 15829563, Free PMC Article
  5. The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information. Hicks SW, et al. J Biol Chem, 2002 Sep 27. PMID 12130652

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia.
    Title: An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia.
  2. Golgin-160 disperses from Golgi membranes in cells subjected to cold temperature. Activated ARF1 can prevent cold-induced dispersal of golgin-160.
    Title: Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.
  3. The golgin-160 binds directly to the third intracellular loop of beta1AR and that this binding depends on three basic residues in this loop.
    Title: Three basic residues of intracellular loop 3 of the beta-1 adrenergic receptor are required for golgin-160-dependent trafficking.
  4. Golgi protein golgin160 recruits dynein to Golgi membranes.
    Title: Golgin160 recruits the dynein motor to position the Golgi apparatus.
  5. A common epitope of proteins golgin-160, voltage-gated potassium channel and disulfide isomerase was identified by screening with autoantibodies of a type 1 diabetic patient
    Title: Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60
    Title: Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160.
  8. results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface
    Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
  9. NH2 terminal domain of Golgin 160 has a role in nuclear transport and Golgi apparatus localization
    Title: The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information.
  10. golgin-160 may promote efficient surface delivery of a subset of cargo molecules
    Title: Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
golgin subfamily A member 3
Names
Golgi membrane associated protein
Golgi peripheral membrane protein
SY2/SY10 protein
golgi autoantigen, golgin subfamily a, 3
golgi complex-associated protein of 170 kDa
golgin-160
golgin-165
male enhanced antigen-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029887.1 RefSeqGene

    Range
    4972..64927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172557.2 → NP_001166028.1  golgin subfamily A member 3 isoform 2

    See identical proteins and their annotated locations for NP_001166028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and contains a different 3' end, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC127070, BC146675, D63997
    Consensus CDS
    CCDS53846.1
    UniProtKB/TrEMBL
    A0A8I5KVX9
    Related
    ENSP00000442603.1, ENST00000545875.4
    Conserved Domains (2) summary
    pfam05010
    Location:812 → 997
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl19219
    Location:812 → 886
    DUF342; Protein of unknown function (DUF342)

  2. NM_001389683.1 → NP_001376612.1  golgin subfamily A member 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS9281.1
    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Related
    ENSP00000410378.2, ENST00000450791.8
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001389684.1 → NP_001376613.1  golgin subfamily A member 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS9281.1
    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001389685.1 → NP_001376614.1  golgin subfamily A member 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS9281.1
    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001389686.1 → NP_001376615.1  golgin subfamily A member 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS91785.1
    UniProtKB/TrEMBL
    A0A8I5KSF0, A0A8I5KWY9
    Related
    ENSP00000510765.1, ENST00000688114.1
    Conserved Domains (2) summary
    COG1196
    Location:590 → 1318
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:353 → 703
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. NM_001389687.1 → NP_001376616.1  golgin subfamily A member 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS91785.1
    UniProtKB/TrEMBL
    A0A8I5KSF0, A0A8I5KWY9
    Conserved Domains (2) summary
    COG1196
    Location:590 → 1318
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:353 → 703
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. NM_001389688.1 → NP_001376617.1  golgin subfamily A member 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    Consensus CDS
    CCDS91785.1
    UniProtKB/TrEMBL
    A0A8I5KSF0, A0A8I5KWY9
    Related
    ENSP00000509869.1, ENST00000691696.1
    Conserved Domains (2) summary
    COG1196
    Location:590 → 1318
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:353 → 703
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. NM_001389689.1 → NP_001376618.1  golgin subfamily A member 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC127070, AC136467
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Conserved Domains (1) summary
    COG1196
    Location:539 → 1267
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. NM_005895.4 → NP_005886.2  golgin subfamily A member 3 isoform 1

    See identical proteins and their annotated locations for NP_005886.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC127070, AC136467, AF485338, BC060826, BF902971, D63997
    Consensus CDS
    CCDS9281.1
    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Related
    ENSP00000204726.3, ENST00000204726.9
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132768914..132829081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428706.1 → XP_047284662.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  2. XM_047428708.1 → XP_047284664.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  3. XM_024448941.2 → XP_024304709.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_047428707.1 → XP_047284663.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  5. XM_024448940.2 → XP_024304708.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3
    UniProtKB/TrEMBL
    A0A8I5KSF0
    Conserved Domains (2) summary
    COG1196
    Location:630 → 1358
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:393 → 743
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_047428705.1 → XP_047284661.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  7. XM_047428709.1 → XP_047284665.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  8. XM_005266167.5 → XP_005266224.1  golgin subfamily A member 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KSF0
    Related
    ENSP00000508770.1, ENST00000690511.1
    Conserved Domains (2) summary
    COG1196
    Location:439 → 1167
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:621 → 695
    DUF342; Protein of unknown function (DUF342)

  9. XM_011534794.3 → XP_011533096.1  golgin subfamily A member 3 isoform X3

    Conserved Domains (3) summary
    TIGR02168
    Location:20 → 694
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01496
    Location:446 → 526
    V_ATPase_I; V-type ATPase 116kDa subunit family
    cl19219
    Location:164 → 238
    DUF342; Protein of unknown function (DUF342)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132819976..132879866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371760.1 → XP_054227735.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  2. XM_054371762.1 → XP_054227737.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  3. XM_054371759.1 → XP_054227734.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  4. XM_054371761.1 → XP_054227736.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  5. XM_054371758.1 → XP_054227733.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  6. XM_054371757.1 → XP_054227732.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  7. XM_054371756.1 → XP_054227731.1  golgin subfamily A member 3 isoform X1

    UniProtKB/Swiss-Prot
    A5PKX6, O43241, Q08378, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3

  8. XM_054371763.1 → XP_054227738.1  golgin subfamily A member 3 isoform X2

  9. XM_054371764.1 → XP_054227739.1  golgin subfamily A member 3 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08378.2 GenPept UniProtKB/Swiss-Prot:Q08378

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