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Duxbl1 double homeobox B-like 1 [ Mus musculus (house mouse) ]

Gene ID: 278672, updated on 2-Apr-2024

Summary

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Official Symbol
Duxbl1provided by MGI
Official Full Name
double homeobox B-like 1provided by MGI
Primary source
MGI:MGI:1916048
See related
Ensembl:ENSMUSG00000048502 AllianceGenome:MGI:1916048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Duxl; Duxbl; Duxbl2; Duxbl3; Gm10391; Gm10394; 1110051B16Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of T cell differentiation. Located in nucleus. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Orthologous to several human genes including DUX4L1 (double homeobox 4 like 1 (pseudogene)); DUX4L2 (double homeobox 4 like 2 (pseudogene)); and DUX4L4 (double homeobox 4 like 4 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 2.8) and 9 other tissues See more
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Genomic context

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Location:
14 A3; 14 15.3 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25979011..25990590)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25978560..25990166)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene cytoplasmic polyadenylated homeobox 1 Neighboring gene ubiquitin specific peptidase 7 pseudogene Neighboring gene predicted gene, 46445 Neighboring gene predicted gene, 34059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development. Kawazu M, et al. J Immunol, 2007 Oct 15. PMID 17911620
  2. Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl. Wu SL, et al. Dev Dyn, 2010 Mar. PMID 20063414
  3. The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection. Klein F, et al. J Exp Med, 2019 Mar 4. PMID 30765463, Free PMC Article
  4. DUX is a non-essential synchronizer of zygotic genome activation. De Iaco A, et al. Development, 2020 Jan 23. PMID 31806660, Free PMC Article
  5. Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice. Bademci G, et al. Proc Natl Acad Sci U S A, 2022 Jun 28. PMID 35727972, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Duxbl is a regulator of beta-selection by inducing apoptosis in T cells with a nonfunctional rearrangement.
    Title: The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.
  2. Duxbl proteins play regulatory roles during myogenesis and reproductive developments
    Title: Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.
  3. Involved in thymocyte development. Knockdown by shRNA impaired CD4/8 double-negative thymocyte differentiation. Overexpression impaired TCR-beta expression and CD4/8 double-positive thymocyte production. Expressed also in B-lymphocytes.
    Title: Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.
Submit: New GeneRIF Correction

General gene information

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Clone Names

  • MGC67567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
double homeobox B-like 1
Names
Dux in lymphoid lineage
doubl homeobox B-like 2
double homeobox B-like 2
double homeobox B-like 3
double homeodomain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183389.2 → NP_899245.1  double homeobox B-like 1

    See identical proteins and their annotated locations for NP_899245.1

    Status: VALIDATED

    Source sequence(s)
    AK141686, BC055782
    Consensus CDS
    CCDS26878.1
    UniProtKB/TrEMBL
    Q7TNE6
    Related
    ENSMUSP00000056056.9, ENSMUST00000049793.9
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    25979011..25990590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158654.1 → XP_036014547.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. XM_030247552.2 → XP_030103412.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  3. XM_036158649.1 → XP_036014542.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  4. XM_036158652.1 → XP_036014545.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  5. XM_011245082.2 → XP_011243384.1  double homeobox B-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011243384.1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  6. XM_036158646.1 → XP_036014539.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  7. XM_036158648.1 → XP_036014541.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  8. XM_030247843.1 → XP_030103703.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  9. XM_011245083.1 → XP_011243385.1  double homeobox B-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011243385.1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  10. XM_036158650.1 → XP_036014543.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  11. XM_036158651.1 → XP_036014544.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  12. XM_036158653.1 → XP_036014546.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  13. XM_030247844.1 → XP_030103704.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  14. XM_030247845.1 → XP_030103705.1  double homeobox B-like 1 isoform X1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  15. XM_006519079.1 → XP_006519142.1  double homeobox B-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006519142.1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  16. XM_006519077.4 → XP_006519140.1  double homeobox B-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006519140.1

    UniProtKB/TrEMBL
    Q7TNE6
    Conserved Domains (2) summary
    smart00389
    Location:95 → 149
    HOX; Homeodomain
    cd00086
    Location:15 → 71
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177538.2: Suppressed sequence

    Description
    NM_001177538.2: This RefSeq was removed because it is redundant with NM_183389.2.

  2. NM_001177539.2: Suppressed sequence

    Description
    NM_001177539.2: This RefSeq was removed because it is redundant with NM_183389.2.
Nucleotide Protein Strain
Heading Accession and Version

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