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Tbl2 transducin (beta)-like 2 [ Mus musculus (house mouse) ]

Gene ID: 27368, updated on 8-May-2024

Summary

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Official Symbol
Tbl2provided by MGI
Official Full Name
transducin (beta)-like 2provided by MGI
Primary source
MGI:MGI:1351652
See related
Ensembl:ENSMUSG00000005374 AllianceGenome:MGI:1351652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WS-bTRP
Summary
Predicted to enable phosphoprotein binding activity; protein kinase binding activity; and translation initiation factor binding activity. Predicted to be involved in cellular response to glucose starvation; cellular response to hypoxia; and endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum. Orthologous to human TBL2 (transducin beta like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.5), limb E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 75.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135178288..135192727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135149429..135163873)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 37D Neighboring gene STARR-seq mESC enhancer starr_14566 Neighboring gene MLX interacting protein-like Neighboring gene STARR-positive B cell enhancer ABC_E855 Neighboring gene STARR-positive B cell enhancer ABC_E280 Neighboring gene STARR-positive B cell enhancer ABC_E6386 Neighboring gene B cell CLL/lymphoma 7B Neighboring gene STARR-seq mESC enhancer starr_14571 Neighboring gene STARR-positive B cell enhancer ABC_E2767 Neighboring gene STARR-seq mESC enhancer starr_14572 Neighboring gene bromodomain adjacent to zinc finger domain, 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. de Luis O, et al. Eur J Hum Genet, 2000 Mar. PMID 10780788
  2. TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog. Pérez Jurado LA, et al. Cytogenet Cell Genet, 1999. PMID 10575226
  3. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, et al. Genomics, 2000 Oct 1. PMID 11013070
  4. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article
  5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transducin beta-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363307.1 → NP_001350236.1  transducin beta-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024607
    Conserved Domains (2) summary
    sd00039
    Location:45 → 89
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:2 → 210
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_013763.3 → NP_038791.2  transducin beta-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_038791.2

    Status: VALIDATED

    Source sequence(s)
    AC024607, AK047090, AK132366, BC048185, BE947541
    Consensus CDS
    CCDS19735.1
    UniProtKB/Swiss-Prot
    Q8CFY0, Q9R099
    UniProtKB/TrEMBL
    Q9CY49
    Related
    ENSMUSP00000115011.2, ENSMUST00000153183.8
    Conserved Domains (3) summary
    COG2319
    Location:82 → 394
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:89 → 132
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:78 → 394
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135178288..135192727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504432.5 → XP_006504495.1  transducin beta-like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q9CY49
    Conserved Domains (2) summary
    sd00039
    Location:60 → 103
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:49 → 365
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_030254546.2 → XP_030110406.1  transducin beta-like protein 2 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:45 → 89
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:2 → 210
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R099.2 GenPept UniProtKB/Swiss-Prot:Q9R099

Gene LinkOut

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