Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdk4provided by MGI
Official Full Name: pyruvate dehydrogenase kinase, isoenzyme 4provided by MGI
Primary source: MGI:MGI:1351481
See related: Ensembl:ENSMUSG00000019577 AllianceGenome:MGI:1351481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including insulin receptor signaling pathway; regulation of bone resorption; and regulation of fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skin. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 42.2), adrenal adult (RPKM 18.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 2.06 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (5483351..5496278, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (5483351..5496278, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy.
Title: Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy.
Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice.
Title: Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice.
WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
Title: WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo.
Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Title: Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Glucocorticoid Receptors Drive Breast Cancer Cell Migration and Metabolic Reprogramming via PDK4.
Title: Glucocorticoid Receptors Drive Breast Cancer Cell Migration and Metabolic Reprogramming via PDK4.
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging.
Title: Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging.
Pyruvate dehydrogenase kinase 4 promotes osteoblastic potential of BMP9 by boosting Wnt/beta-catenin signaling in mesenchymal stem cells.
Title: Pyruvate dehydrogenase kinase 4 promotes osteoblastic potential of BMP9 by boosting Wnt/β-catenin signaling in mesenchymal stem cells.
Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system-dependent muscle atrophy.
Title: Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system-dependent muscle atrophy.
MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
Title: MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Title: PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AJ001418 (e-PCR)
- UniSTS:163381

Pdk4 (e-PCR), detects polymorphism
- UniSTS:527484

AV005916 (e-PCR)
- UniSTS:179332

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of acetyl-CoA biosynthetic process from pyruvate	TAS Traceable Author Statement more info	PubMed
involved_in regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular ketone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Names: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase 4

NP_038771.1

EC 2.7.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013743.2 → NP_038771.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

See identical proteins and their annotated locations for NP_038771.1

Status: PROVISIONAL

Source sequence(s)

AC023174

Consensus CDS

CCDS19902.1

UniProtKB/Swiss-Prot

O70571

UniProtKB/TrEMBL

Q544J2

Related

ENSMUSP00000019721.5, ENSMUST00000019721.7

Conserved Domains (3) summary

smart00387
Location:245 → 365

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:245 → 373

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:34 → 195

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase