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Acsm5 acyl-CoA synthetase medium-chain family member 5 [ Mus musculus (house mouse) ]

Gene ID: 272428, updated on 28-Apr-2024

Summary

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Official Symbol
Acsm5provided by MGI
Official Full Name
acyl-CoA synthetase medium-chain family member 5provided by MGI
Primary source
MGI:MGI:2444086
See related
Ensembl:ENSMUSG00000030972 AllianceGenome:MGI:2444086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C730019D22; C730027J19Rik
Summary
Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in axial skeleton; basisphenoid bone; and thoracic segment skeleton. Orthologous to human ACSM5 (acyl-CoA synthetase medium chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 23.3) and kidney adult (RPKM 20.2) See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 63.94 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119125354..119142583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119526131..119543360)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 zymogen granule membrane Neighboring gene uromodulin Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene predicted gene, 39078

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway.
    Title: ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM5, mitochondrial
NP_848873.1
XP_006507967.1
XP_006507968.1
XP_011240127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178758.3 → NP_848873.1  acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

    See identical proteins and their annotated locations for NP_848873.1

    Status: VALIDATED

    Source sequence(s)
    BC095985
    Consensus CDS
    CCDS40106.1
    UniProtKB/Swiss-Prot
    Q8BGA8, Q8BJS0, Q8BM02, Q8BWQ8, Q8BWS7
    UniProtKB/TrEMBL
    A0A140LHR8
    Related
    ENSMUSP00000063416.2, ENSMUST00000066465.3
    Conserved Domains (2) summary
    COG0365
    Location:48 → 572
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:48 → 576
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119125354..119142583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507905.2 → XP_006507968.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006507968.1

    Conserved Domains (1) summary
    cl17068
    Location:22 → 343
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_006507904.2 → XP_006507967.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006507967.1

    UniProtKB/TrEMBL
    A0A140LHR8
    Conserved Domains (1) summary
    cl17068
    Location:61 → 589
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. XM_011241825.4 → XP_011240127.1  acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011240127.1

    Conserved Domains (1) summary
    cl17068
    Location:22 → 343
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGA8.1 GenPept UniProtKB/Swiss-Prot:Q8BGA8

Gene LinkOut

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