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Sh3d19 SH3 domain protein D19 [ Mus musculus (house mouse) ]

Gene ID: 27059, updated on 5-Mar-2024

Summary

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Official Symbol
Sh3d19provided by MGI
Official Full Name
SH3 domain protein D19provided by MGI
Primary source
MGI:MGI:1350923
See related
Ensembl:ENSMUSG00000028082 AllianceGenome:MGI:1350923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kryn
Summary
Predicted to enable proline-rich region binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of membrane protein ectodomain proteolysis; and regulation of cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in gut; metanephros; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human SH3D19 (SH3 domain containing 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 21.0), colon adult (RPKM 8.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 37.83 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (85878112..86037833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (85970805..86130526)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9790 Neighboring gene STARR-seq mESC enhancer starr_08116 Neighboring gene STARR-seq mESC enhancer starr_08117 Neighboring gene predicted gene, 27811 Neighboring gene STARR-seq mESC enhancer starr_08123 Neighboring gene STARR-seq mESC enhancer starr_08124 Neighboring gene serine protease 48 Neighboring gene predicted gene, 25188 Neighboring gene small nucleolar RNA, C/D box U73A Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles. Shimomura Y, et al. J Dermatol Sci, 2003 Feb. PMID 12615363
  2. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein 19
Names
SH3 domain containing protein D 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082414.3 → NP_001075883.3  SH3 domain-containing protein 19 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC133508, AC138528
    Consensus CDS
    CCDS38469.2
    UniProtKB/TrEMBL
    A0A571BGG1
    Related
    ENSMUSP00000158832.2, ENSMUST00000238545.2
    Conserved Domains (4) summary
    cd11814
    Location:635 → 684
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:791 → 841
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:38 → 559
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:715 → 766
    SH3; Src Homology 3 domain superfamily

  2. NM_001374679.1 → NP_001361608.1  SH3 domain-containing protein 19 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC133508, AC138528
    Consensus CDS
    CCDS89646.1
    UniProtKB/TrEMBL
    A0A571BGG1
    Conserved Domains (4) summary
    cd11814
    Location:635 → 684
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:791 → 841
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:38 → 559
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:715 → 766
    SH3; Src Homology 3 domain superfamily

  3. NM_001404299.1 → NP_001391228.1  SH3 domain-containing protein 19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133508, AC138528
    UniProtKB/TrEMBL
    A0A571BEF4
    Related
    ENSMUSP00000158699.2, ENSMUST00000238443.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    85878112..86037833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319605.3 → XP_017175094.2  SH3 domain-containing protein 19 isoform X5

    Conserved Domains (2) summary
    PTZ00449
    Location:245 → 666
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:50 → 375
    PHA03247; large tegument protein UL36; Provisional

  2. XM_011240136.4 → XP_011238438.1  SH3 domain-containing protein 19 isoform X4

    See identical proteins and their annotated locations for XP_011238438.1

    UniProtKB/Swiss-Prot
    O08635, O35146, Q8C7I2, Q91X43
    Related
    ENSMUSP00000138320.2, ENSMUST00000182666.8
    Conserved Domains (4) summary
    cd11814
    Location:419 → 468
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:575 → 625
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:25 → 305
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:499 → 550
    SH3; Src Homology 3 domain superfamily

  3. XM_011240135.4 → XP_011238437.1  SH3 domain-containing protein 19 isoform X2

    Conserved Domains (4) summary
    cd11814
    Location:700 → 749
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:856 → 906
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:103 → 624
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:780 → 831
    SH3; Src Homology 3 domain superfamily

  4. XM_006501547.4 → XP_006501610.1  SH3 domain-containing protein 19 isoform X3

    See identical proteins and their annotated locations for XP_006501610.1

    UniProtKB/TrEMBL
    A0A571BGG1
    Conserved Domains (4) summary
    cd11814
    Location:635 → 684
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:791 → 841
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:38 → 559
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:715 → 766
    SH3; Src Homology 3 domain superfamily

  5. XM_006501550.5 → XP_006501613.1  SH3 domain-containing protein 19 isoform X4

    See identical proteins and their annotated locations for XP_006501613.1

    UniProtKB/Swiss-Prot
    O08635, O35146, Q8C7I2, Q91X43
    Related
    ENSMUSP00000158600.2, ENSMUST00000238331.2
    Conserved Domains (4) summary
    cd11814
    Location:419 → 468
    SH3_Eve1_1; First Src homology 3 domain of ADAM-binding protein Eve-1
    cd11816
    Location:575 → 625
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:25 → 305
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:499 → 550
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_003954328.2 RNA Sequence

  2. XR_004941332.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012059.2: Suppressed sequence

    Description
    NM_012059.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X43.2 GenPept UniProtKB/Swiss-Prot:Q91X43

Gene LinkOut

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