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Tpsg1 tryptase gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 26945, updated on 11-Apr-2024

Summary

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Official Symbol
Tpsg1provided by MGI
Official Full Name
tryptase gamma 1provided by MGI
Primary source
MGI:MGI:1349391
See related
Ensembl:ENSMUSG00000033200 AllianceGenome:MGI:1349391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmt; Prss31
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human TPSG1 (tryptase gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 51.6), large intestine adult (RPKM 22.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25588169..25593416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25369195..25374442)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tryptase alpha/beta 1 Neighboring gene STARR-seq mESC enhancer starr_42106 Neighboring gene tryptase beta 2 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene tektin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. Hansbro PM, et al. J Biol Chem, 2014 Jun 27. PMID 24821729, Free PMC Article
  2. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. Wong GW, et al. J Biol Chem, 1999 Oct 22. PMID 10521469
  3. Murine implantation serine proteinases 1 and 2: structure, function and evolution. Tang L, et al. Gene, 2005 Dec 30. PMID 16257142
  4. Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. Caughey GH, et al. J Immunol, 2000 Jun 15. PMID 10843716
  5. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prss31-null mice had increased airway reactivity to methacholine but markedly reduced experimental chronic obstructive pulmonary disease and colitis.
    Title: Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tryptase gamma
Names
transmembrane tryptase
NP_001344655.1
NP_001398260.1
NP_001398261.1
NP_001398262.1
NP_036164.2
XP_006524421.1
XP_006524423.1
XP_006524426.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357726.1 → NP_001344655.1  tryptase gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122454, AK027982
    Consensus CDS
    CCDS89021.1
    UniProtKB/TrEMBL
    E0CXD8, G3XA07
    Related
    ENSMUSP00000124008.2, ENSMUST00000160377.9
    Conserved Domains (1) summary
    cd00190
    Location:14 → 157
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001411331.1 → NP_001398260.1  tryptase gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122454
    UniProtKB/TrEMBL
    G3XA07
    Related
    ENSMUSP00000124721.3, ENSMUST00000160485.9

  3. NM_001411332.1 → NP_001398261.1  tryptase gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122454
    UniProtKB/TrEMBL
    G3XA07
    Related
    ENSMUSP00000159911.1, ENSMUST00000249747.1

  4. NM_001411333.1 → NP_001398262.1  tryptase gamma isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122454
    UniProtKB/TrEMBL
    E9Q7E3
    Related
    ENSMUSP00000125180.2, ENSMUST00000162021.9

  5. NM_012034.4 → NP_036164.2  tryptase gamma isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122454
    Consensus CDS
    CCDS28518.1
    UniProtKB/Swiss-Prot
    Q9QUL7
    UniProtKB/TrEMBL
    D5L840, E9QLD4
    Related
    ENSMUSP00000024999.9, ENSMUST00000024999.16
    Conserved Domains (2) summary
    smart00020
    Location:29 → 257
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30 → 260
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25588169..25593416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524358.3 → XP_006524421.1  tryptase gamma isoform X1

    UniProtKB/Swiss-Prot
    Q9QUL7
    UniProtKB/TrEMBL
    D5L840
    Conserved Domains (1) summary
    cd00190
    Location:87 → 317
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_006524363.1 → XP_006524426.1  tryptase gamma isoform X2

    See identical proteins and their annotated locations for XP_006524426.1

    UniProtKB/TrEMBL
    E0CXD8, G3XA07
    Conserved Domains (1) summary
    cd00190
    Location:14 → 157
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_006524360.1 → XP_006524423.1  tryptase gamma isoform X3

    UniProtKB/Swiss-Prot
    Q9QUL7
    UniProtKB/TrEMBL
    D5L840
    Conserved Domains (1) summary
    cd00190
    Location:41 → 271
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUL7.1 GenPept UniProtKB/Swiss-Prot:Q9QUL7

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