U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mprip myosin phosphatase Rho interacting protein [ Mus musculus (house mouse) ]

Gene ID: 26936, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mpripprovided by MGI
Official Full Name
myosin phosphatase Rho interacting proteinprovided by MGI
Primary source
MGI:MGI:1349438
See related
Ensembl:ENSMUSG00000005417 AllianceGenome:MGI:1349438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIP3; Rhoip3; Gm34094; p116Rip; mKIAA0864; 9530046C02
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; maintenance of protein location in cell; and regulation of protein modification process. Predicted to be located in cytosol and stress fiber. Predicted to be active in actin cytoskeleton. Is expressed in central nervous system and peripheral nervous system ganglion. Orthologous to human MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Mprip (Gene ID: 26936) and Ripk3 (Gene ID: 56532) share the RIP3 symbol/alias in common. RIP3 is a widely used alternative name for Ripk3 (Gene ID: 56532), which can be confused with Mprip (Gene ID: 26936), which also uses RIP3 as an alternative name. [05 Mar 2019]
Expression
Ubiquitous expression in lung adult (RPKM 20.1), testis adult (RPKM 18.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B1.3; 11 37.76 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59552973..59671686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59662470..59780862)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily W member 25 Neighboring gene predicted gene, 33998 Neighboring gene STARR-positive B cell enhancer mm9_chr11:59475741-59476042 Neighboring gene RIKEN cDNA 1700007J10 gene Neighboring gene predicted gene, 51899 Neighboring gene phospholipase D family member 6 Neighboring gene folliculin Neighboring gene predicted gene 16062

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein. Choi H, et al. FASEB J, 2023 Jul. PMID 37310356, Free PMC Article
  2. p116Rip is a novel filamentous actin-binding protein. Mulder J, et al. J Biol Chem, 2003 Jul 18. PMID 12732640
  3. p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. Mulder J, et al. Mol Biol Cell, 2004 Dec. PMID 15469989, Free PMC Article
  4. Inhibition of RhoA-mediated SRF activation by p116Rip. Mulder J, et al. FEBS Lett, 2005 Nov 7. PMID 16243315
  5. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. Gebbink MF, et al. J Cell Biol, 1997 Jun 30. PMID 9199174, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC67316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myosin phosphatase Rho-interacting protein
Names
Rho interacting protein 3
Rho-interacting protein 3 (p116RIP) (RIP3)
p116 Rho interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368931.2 → NP_001355860.1  myosin phosphatase Rho-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596204
    Conserved Domains (6) summary
    TIGR00618
    Location:895 → 1576
    sbcc; exonuclease SbcC
    COG1196
    Location:895 → 1214
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2133 → 2400
    PRK03918; chromosome segregation protein; Provisional
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:507 → 608
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:1886 → 2240
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_012027.2 → NP_036157.2  myosin phosphatase Rho-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_036157.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK158296, AL596204, BC049803, CJ130801
    Consensus CDS
    CCDS24775.1
    UniProtKB/Swiss-Prot
    P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8
    UniProtKB/TrEMBL
    F6S5I0
    Related
    ENSMUSP00000112072.2, ENSMUST00000116371.8
    Conserved Domains (5) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:389 → 490
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:389 → 477
    PH; PH domain
    cl02488
    Location:737 → 975
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl03951
    Location:638 → 756
    CDC37_N; Cdc37 N terminal kinase binding

  3. NM_201245.3 → NP_957697.1  myosin phosphatase Rho-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_957697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AK158296, AL596204, CJ130801
    Consensus CDS
    CCDS24774.1
    UniProtKB/TrEMBL
    F6S5I0
    Related
    ENSMUSP00000071914.7, ENSMUST00000072031.13
    Conserved Domains (5) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:389 → 490
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:389 → 477
    PH; PH domain
    cl02488
    Location:737 → 975
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl03951
    Location:638 → 756
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59552973..59671686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314568.3 → XP_017170057.1  myosin phosphatase Rho-interacting protein isoform X1

    Conserved Domains (6) summary
    TIGR00618
    Location:895 → 1576
    sbcc; exonuclease SbcC
    COG1196
    Location:895 → 1214
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2133 → 2400
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:507 → 608
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:1886 → 2240
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_030246039.2 → XP_030101899.1  myosin phosphatase Rho-interacting protein isoform X13

    Conserved Domains (4) summary
    COG4372
    Location:795 → 1060
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:507 → 608
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:932 → 1227
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006533439.3 → XP_006533502.1  myosin phosphatase Rho-interacting protein isoform X16

    UniProtKB/TrEMBL
    F6RND9
    Related
    ENSMUSP00000119562.2, ENSMUST00000133861.8
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:507 → 608
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:780 → 1090
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006533438.3 → XP_006533501.1  myosin phosphatase Rho-interacting protein isoform X15

    UniProtKB/TrEMBL
    F6RND9
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:507 → 608
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:780 → 1090
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_036156726.1 → XP_036012619.1  myosin phosphatase Rho-interacting protein isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:872 → 1191
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:728 → 973
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl17171
    Location:507 → 585
    PH-like; Pleckstrin homology-like domain

  6. XM_006533428.3 → XP_006533491.1  myosin phosphatase Rho-interacting protein isoform X3

    Conserved Domains (6) summary
    TIGR00618
    Location:859 → 1540
    sbcc; exonuclease SbcC
    COG1196
    Location:859 → 1178
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2097 → 2364
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:471 → 572
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:1850 → 2204
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  7. XM_030246040.2 → XP_030101900.1  myosin phosphatase Rho-interacting protein isoform X17

    UniProtKB/TrEMBL
    F6RND9
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:471 → 572
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:744 → 1054
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_036156727.1 → XP_036012620.1  myosin phosphatase Rho-interacting protein isoform X4

    Conserved Domains (4) summary
    COG1196
    Location:836 → 1155
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:692 → 937
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl17171
    Location:471 → 549
    PH-like; Pleckstrin homology-like domain

  9. XM_006533432.3 → XP_006533495.1  myosin phosphatase Rho-interacting protein isoform X7

    Conserved Domains (6) summary
    TIGR00618
    Location:777 → 1458
    sbcc; exonuclease SbcC
    COG1196
    Location:777 → 1096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2015 → 2282
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:389 → 490
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:1768 → 2122
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  10. XM_036156733.1 → XP_036012626.1  myosin phosphatase Rho-interacting protein isoform X14

    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:389 → 490
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:662 → 998
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_036156729.1 → XP_036012622.1  myosin phosphatase Rho-interacting protein isoform X8

    Conserved Domains (4) summary
    COG1196
    Location:754 → 1073
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:610 → 855
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl17171
    Location:389 → 467
    PH-like; Pleckstrin homology-like domain

  12. XM_036156734.1 → XP_036012627.1  myosin phosphatase Rho-interacting protein isoform X18

    UniProtKB/TrEMBL
    F6S5I0
    Conserved Domains (3) summary
    COG1196
    Location:639 → 952
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cl17171
    Location:389 → 467
    PH-like; Pleckstrin homology-like domain

  13. XM_006533433.3 → XP_006533496.1  myosin phosphatase Rho-interacting protein isoform X9

    UniProtKB/TrEMBL
    Q5SWZ5
    Related
    ENSMUSP00000071081.9, ENSMUST00000066330.15
    Conserved Domains (6) summary
    TIGR00618
    Location:741 → 1422
    sbcc; exonuclease SbcC
    COG1196
    Location:741 → 1060
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:353 → 454
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:1978 → 2206
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:1732 → 2086
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  14. XM_006533441.3 → XP_006533504.1  myosin phosphatase Rho-interacting protein isoform X20

    UniProtKB/TrEMBL
    F6S5I0
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:353 → 454
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:626 → 936
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. XM_006533440.3 → XP_006533503.1  myosin phosphatase Rho-interacting protein isoform X19

    UniProtKB/TrEMBL
    F6S5I0
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:353 → 454
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:626 → 936
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  16. XM_030246041.1 → XP_030101901.1  myosin phosphatase Rho-interacting protein isoform X21

    UniProtKB/TrEMBL
    F6S5I0
    Related
    ENSMUSP00000119422.2, ENSMUST00000132620.8
    Conserved Domains (2) summary
    cd13275
    Location:293 → 394
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:566 → 876
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  17. XM_011249055.2 → XP_011247357.2  myosin phosphatase Rho-interacting protein isoform X6

    Conserved Domains (3) summary
    COG1196
    Location:799 → 1118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:411 → 512
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:655 → 900
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  18. XM_036156731.1 → XP_036012624.1  myosin phosphatase Rho-interacting protein isoform X11

    Conserved Domains (3) summary
    COG1196
    Location:789 → 1108
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:401 → 502
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:645 → 890
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  19. XM_036156728.1 → XP_036012621.1  myosin phosphatase Rho-interacting protein isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:817 → 1136
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:429 → 530
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:673 → 918
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  20. XM_036156730.1 → XP_036012623.1  myosin phosphatase Rho-interacting protein isoform X10

    Conserved Domains (3) summary
    COG1196
    Location:699 → 1018
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:311 → 412
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:555 → 800
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  21. XM_036156732.1 → XP_036012625.1  myosin phosphatase Rho-interacting protein isoform X12

    UniProtKB/TrEMBL
    Q8CHC7
    Conserved Domains (4) summary
    COG1196
    Location:479 → 798
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:91 → 192
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:1438 → 1729
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:335 → 580
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RNA

  1. XR_003949455.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97434.2 GenPept UniProtKB/Swiss-Prot:P97434

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous