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Arhgap28 Rho GTPase activating protein 28 [ Mus musculus (house mouse) ]

Gene ID: 268970, updated on 30-Apr-2024

Summary

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Official Symbol
Arhgap28provided by MGI
Official Full Name
Rho GTPase activating protein 28provided by MGI
Primary source
MGI:MGI:2147003
See related
Ensembl:ENSMUSG00000024043 AllianceGenome:MGI:2147003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130310N06
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of GTP binding activity and negative regulation of stress fiber assembly. Predicted to be active in cytoplasm. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 7.1), ovary adult (RPKM 4.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.1- E1.2; 17 38.9 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68149701..68311185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (67842706..68004197, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52321 Neighboring gene leucine rich repeat containing 30 Neighboring gene laminin, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312 Neighboring gene L3MBTL4 histone methyl-lysine binding protein Neighboring gene peroxiredoxin 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. Yeung CY, et al. PLoS One, 2014. PMID 25211221, Free PMC Article
  2. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. Santos R, et al. PLoS Biol, 2016 Sep. PMID 27606604, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Müller PM, et al. Nat Cell Biol, 2020 Apr. PMID 32203420
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 28
Names
rho-type GTPase-activating protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347410.1 → NP_001334339.1  rho GTPase-activating protein 28 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154823, AC164159, CO043770
    Consensus CDS
    CCDS84329.1
    UniProtKB/TrEMBL
    A0A2X0SYT7
    Related
    ENSMUSP00000130960.2, ENSMUST00000163865.8

  2. NM_001426794.1 → NP_001413723.1  rho GTPase-activating protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154823, AC164159
    UniProtKB/TrEMBL
    E9Q642

  3. NM_001426795.1 → NP_001413724.1  rho GTPase-activating protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154823, AC164159
    UniProtKB/TrEMBL
    E9Q642

  4. NM_172964.4 → NP_766552.3  rho GTPase-activating protein 28 isoform 1

    See identical proteins and their annotated locations for NP_766552.3

    Status: VALIDATED

    Source sequence(s)
    AK087523, AK133720, AK141901, BB372888
    Consensus CDS
    CCDS28950.1
    UniProtKB/Swiss-Prot
    Q3TSH7, Q3UR11, Q3UZQ7, Q69ZM1, Q6NY11, Q8BN58
    UniProtKB/TrEMBL
    A0A2X0SYT7
    Related
    ENSMUSP00000024840.6, ENSMUST00000024840.12
    Conserved Domains (1) summary
    cd04391
    Location:381 → 592
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    68149701..68311185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160630.1 → XP_036016523.1  rho GTPase-activating protein 28 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SYT7
    Conserved Domains (1) summary
    cd04391
    Location:408 → 619
    RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  2. XM_006524343.5 → XP_006524406.1  rho GTPase-activating protein 28 isoform X2

    See identical proteins and their annotated locations for XP_006524406.1

    UniProtKB/TrEMBL
    A0A2X0SYT7, E9Q642
    Conserved Domains (1) summary
    cd04391
    Location:331 → 542
    RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BN58.1 GenPept UniProtKB/Swiss-Prot:Q8BN58

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