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Homer3 homer scaffolding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 26558, updated on 11-Apr-2024

Summary

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Official Symbol
Homer3provided by MGI
Official Full Name
homer scaffolding protein 3provided by MGI
Primary source
MGI:MGI:1347359
See related
Ensembl:ENSMUSG00000003573 AllianceGenome:MGI:1347359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein C-terminus binding activity and protein domain specific binding activity. Involved in regulation of postsynaptic neurotransmitter receptor activity. Located in basal part of cell; cytosol; and glutamatergic synapse. Is active in postsynaptic density. Is expressed in several structures, including alimentary system; brain; cranial ganglion; cranial nerve; and sensory organ. Orthologous to human HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 62.8), ovary adult (RPKM 38.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Homer3 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70735529..70747011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70282880..70294361)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene SURP and G patch domain containing 2 Neighboring gene predicted gene, 38427 Neighboring gene STARR-positive B cell enhancer ABC_E8240 Neighboring gene DEAD box helicase 49 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 RNA helicase and ATPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism. Son A, et al. J Endocrinol, 2019 Sep. PMID 31319381, Free PMC Article
  2. Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues. Reibring CG, et al. Int J Mol Sci, 2020 Feb 13. PMID 32070057, Free PMC Article
  3. Differential expression of Homer family proteins in the developing mouse brain. Shiraishi Y, et al. J Comp Neurol, 2004 Jun 7. PMID 15116392
  4. HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer. Liu Q, et al. J Hematol Oncol, 2021 Jan 6. PMID 33407765, Free PMC Article
  5. Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Parisiadou L, et al. Neurobiol Dis, 2008 Jun. PMID 18387811

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.
    Title: HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.
  2. Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
    Title: Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
  3. Data indicate decreased bone density in homer scaffolding proteins (Homer2/3) double knockout (DKO) mice.
    Title: Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.
  4. impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia type 1 and presents a promising therapeutic target
    Title: Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
  5. Homer2 and Homer3 proteins interact specifically with amyloid precursor protein (APP) by inhibiting APP processing and reducing secretion of Abeta peptides.
    Title: Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
  6. Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity.
    Title: Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells.
  7. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin
    Title: NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
  8. Expression of Homer 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons.
    Title: Differential expression of Homer family proteins in the developing mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homer protein homolog 3
Names
homer homolog 3
homer, neuronal immediate early gene, 3
homer-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146153.1 → NP_001139625.1  homer protein homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001139625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158553, BU054773, CX208892
    Consensus CDS
    CCDS52569.1
    UniProtKB/Swiss-Prot
    Q99JP6
    Related
    ENSMUSP00000105751.3, ENSMUST00000110124.9
    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:166 → 354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_011984.2 → NP_036114.2  homer protein homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_036114.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC158553, BU054773, CX208892
    Consensus CDS
    CCDS22363.1
    UniProtKB/Swiss-Prot
    D3Z6N9, Q99JP6, Q9Z215
    Related
    ENSMUSP00000117033.2, ENSMUST00000140212.8
    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:167 → 353
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70735529..70747011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509679.3 → XP_006509742.1  homer protein homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_006509742.1

    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:166 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036154063.1 → XP_036009956.1  homer protein homolog 3 isoform X7

    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:197 → 329
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_030243589.2 → XP_030099449.1  homer protein homolog 3 isoform X9

    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  4. XM_006509681.4 → XP_006509744.1  homer protein homolog 3 isoform X10

    Conserved Domains (2) summary
    TIGR02168
    Location:166 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:56 → 114
    PH-like; Pleckstrin homology-like domain

  5. XM_030243588.2 → XP_030099448.1  homer protein homolog 3 isoform X5

    Conserved Domains (2) summary
    TIGR02168
    Location:166 → 354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:56 → 114
    PH-like; Pleckstrin homology-like domain

  6. XM_030243587.1 → XP_030099447.1  homer protein homolog 3 isoform X4

    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:166 → 354
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_036154064.1 → XP_036009957.1  homer protein homolog 3 isoform X8

    Conserved Domains (1) summary
    cl17171
    Location:58 → 116
    PH-like; Pleckstrin homology-like domain

  8. XM_036154060.1 → XP_036009953.1  homer protein homolog 3 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:153 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:58 → 116
    PH-like; Pleckstrin homology-like domain

  9. XM_036154062.1 → XP_036009955.1  homer protein homolog 3 isoform X6

    Conserved Domains (2) summary
    TIGR02168
    Location:199 → 331
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:58 → 116
    PH-like; Pleckstrin homology-like domain

  10. XM_006509680.4 → XP_006509743.1  homer protein homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_006509743.1

    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:166 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_036154061.1 → XP_036009954.1  homer protein homolog 3 isoform X3

    Conserved Domains (2) summary
    TIGR02168
    Location:168 → 341
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:58 → 116
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_004934834.1 RNA Sequence

  2. XR_003947286.2 RNA Sequence

  3. XR_004934832.1 RNA Sequence

  4. XR_004934833.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JP6.2 GenPept UniProtKB/Swiss-Prot:Q99JP6

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