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Mok MOK protein kinase [ Mus musculus (house mouse) ]

Gene ID: 26448, updated on 11-Apr-2024

Summary

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Official Symbol
Mokprovided by MGI
Official Full Name
MOK protein kinaseprovided by MGI
Primary source
MGI:MGI:1336881
See related
Ensembl:ENSMUSG00000056458 AllianceGenome:MGI:1336881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rage; RAGE1; Stk30
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Located in ciliary base and nucleus. Is expressed in gonad. Orthologous to human MOK (MOK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 13.5), CNS E18 (RPKM 1.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Mok in Genome Data Viewer
Location:
12 F1; 12 60.81 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110770404..110807391, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110807798..110840962, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene WD repeat domain 20 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865 Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Lutterloh EC, et al. Crit Care, 2007. PMID 18042296, Free PMC Article
  2. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Pérez-Cabello JA, et al. Proc Natl Acad Sci U S A, 2023 Jul 11. PMID 37399380, Free PMC Article
  3. Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury. Zeng S, et al. J Hepatol, 2009 May. PMID 19303658
  4. RAGE ligation affects T cell activation and controls T cell differentiation. Chen Y, et al. J Immunol, 2008 Sep 15. PMID 18768885, Free PMC Article
  5. Diabetes, leukoencephalopathy and rage. Toth C, et al. Neurobiol Dis, 2006 Aug. PMID 16815028

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
    Title: Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
  2. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
    Title: MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
  3. This provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activation in amyotrophic lateral sclerosis.
    Title: Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.
  4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
    Title: Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity.
  5. Suppression of Egr-1 may contribute to the protective mechanisms underlying the beneficial impact of RAGE blockade or deletion in hepatic ischemia/reperfusion injury.
    Title: Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury.
  6. RAGE inactivation inhibits the atherosclerosis through reducing oxLDL-induced pro-inflammatory responses and oxidative stress in hyperlipidaemia.
    Title: RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.
  7. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2
    Title: Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Clone Names

  • MGC46883, MGC107277

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAPK/MAK/MRK overlapping kinase
Names
T/STK 30
renal tumor antigen
serine/threonine kinase 30
NP_001404448.1
NP_001404449.1
NP_001404450.1
NP_001404451.1
NP_001404452.1
NP_001404453.1
NP_001404454.1
NP_001404455.1
NP_001404456.1
NP_001404457.1
NP_001404458.1
NP_001404459.1
NP_001404460.1
NP_001404461.1
NP_001404462.1
NP_001404463.1
NP_001404464.1
NP_001404465.1
NP_001404466.1
NP_001410418.1
NP_036103.1
XP_006515949.1
XP_006515953.1
XP_006515955.1
XP_017170559.1
XP_017170560.1
XP_030102571.1
XP_030102576.1
XP_030102578.1
XP_030102583.1
XP_030102585.1
XP_036013304.1
XP_036013305.1
XP_036013306.1
XP_036013308.1
XP_036013310.1
XP_036013311.1
XP_036013313.1
XP_036013315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417519.1 → NP_001404448.1  MAPK/MAK/MRK overlapping kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  2. NM_001417520.1 → NP_001404449.1  MAPK/MAK/MRK overlapping kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  3. NM_001417521.1 → NP_001404450.1  MAPK/MAK/MRK overlapping kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  4. NM_001417522.1 → NP_001404451.1  MAPK/MAK/MRK overlapping kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  5. NM_001417523.1 → NP_001404452.1  MAPK/MAK/MRK overlapping kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  6. NM_001417524.1 → NP_001404453.1  MAPK/MAK/MRK overlapping kinase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  7. NM_001417525.1 → NP_001404454.1  MAPK/MAK/MRK overlapping kinase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265
    UniProtKB/TrEMBL
    Q5M8P5
    Related
    ENSMUSP00000082041.5, ENSMUST00000084974.11

  8. NM_001417526.1 → NP_001404455.1  MAPK/MAK/MRK overlapping kinase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  9. NM_001417527.1 → NP_001404456.1  MAPK/MAK/MRK overlapping kinase isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  10. NM_001417528.1 → NP_001404457.1  MAPK/MAK/MRK overlapping kinase isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  11. NM_001417529.1 → NP_001404458.1  MAPK/MAK/MRK overlapping kinase isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  12. NM_001417530.1 → NP_001404459.1  MAPK/MAK/MRK overlapping kinase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  13. NM_001417531.1 → NP_001404460.1  MAPK/MAK/MRK overlapping kinase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  14. NM_001417532.1 → NP_001404461.1  MAPK/MAK/MRK overlapping kinase isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  15. NM_001417533.1 → NP_001404462.1  MAPK/MAK/MRK overlapping kinase isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  16. NM_001417534.1 → NP_001404463.1  MAPK/MAK/MRK overlapping kinase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  17. NM_001417535.1 → NP_001404464.1  MAPK/MAK/MRK overlapping kinase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  18. NM_001417536.1 → NP_001404465.1  MAPK/MAK/MRK overlapping kinase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  19. NM_001417537.1 → NP_001404466.1  MAPK/MAK/MRK overlapping kinase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  20. NM_001423489.1 → NP_001410418.1  MAPK/MAK/MRK overlapping kinase isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

  21. NM_011973.3 → NP_036103.1  MAPK/MAK/MRK overlapping kinase isoform 1

    See identical proteins and their annotated locations for NP_036103.1

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265
    Consensus CDS
    CCDS49176.1
    UniProtKB/Swiss-Prot
    Q8CFU4, Q9WVS4
    Related
    ENSMUSP00000068904.9, ENSMUST00000070565.15
    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4 → 285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

RNA

  1. NR_184527.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC101875, AL596265

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110770404..110807391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157412.1 → XP_036013305.1  MAPK/MAK/MRK overlapping kinase isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:1 → 193
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030246711.2 → XP_030102571.1  MAPK/MAK/MRK overlapping kinase isoform X6

    Conserved Domains (1) summary
    cd07831
    Location:4 → 234
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

  3. XM_006515886.3 → XP_006515949.1  MAPK/MAK/MRK overlapping kinase isoform X2

    Conserved Domains (1) summary
    cd07831
    Location:4 → 285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

  4. XM_006515892.3 → XP_006515955.1  MAPK/MAK/MRK overlapping kinase isoform X12

    See identical proteins and their annotated locations for XP_006515955.1

    Conserved Domains (1) summary
    cl21453
    Location:3 → 180
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030246718.2 → XP_030102578.1  MAPK/MAK/MRK overlapping kinase isoform X17

    Conserved Domains (1) summary
    cl21453
    Location:1 → 150
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036157411.1 → XP_036013304.1  MAPK/MAK/MRK overlapping kinase isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030246723.2 → XP_030102583.1  MAPK/MAK/MRK overlapping kinase isoform X19

    Conserved Domains (1) summary
    cl21453
    Location:3 → 129
    PKc_like; Protein Kinases, catalytic domain

  8. XM_036157420.1 → XP_036013313.1  MAPK/MAK/MRK overlapping kinase isoform X21

    Conserved Domains (1) summary
    cl21453
    Location:3 → 129
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036157418.1 → XP_036013311.1  MAPK/MAK/MRK overlapping kinase isoform X19

    Conserved Domains (1) summary
    cl21453
    Location:3 → 129
    PKc_like; Protein Kinases, catalytic domain

  10. XM_036157413.1 → XP_036013306.1  MAPK/MAK/MRK overlapping kinase isoform X12

    Conserved Domains (1) summary
    cl21453
    Location:3 → 180
    PKc_like; Protein Kinases, catalytic domain

  11. XM_036157422.1 → XP_036013315.1  MAPK/MAK/MRK overlapping kinase isoform X22

    Conserved Domains (1) summary
    cl21453
    Location:3 → 129
    PKc_like; Protein Kinases, catalytic domain

  12. XM_030246725.2 → XP_030102585.1  MAPK/MAK/MRK overlapping kinase isoform X20

    Conserved Domains (1) summary
    cl21453
    Location:1 → 150
    PKc_like; Protein Kinases, catalytic domain

  13. XM_030246716.2 → XP_030102576.1  MAPK/MAK/MRK overlapping kinase isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:1 → 150
    PKc_like; Protein Kinases, catalytic domain

  14. XM_036157417.1 → XP_036013310.1  MAPK/MAK/MRK overlapping kinase isoform X18

    Conserved Domains (1) summary
    cl21453
    Location:3 → 129
    PKc_like; Protein Kinases, catalytic domain

  15. XM_036157415.1 → XP_036013308.1  MAPK/MAK/MRK overlapping kinase isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:1 → 150
    PKc_like; Protein Kinases, catalytic domain

  16. XM_017315070.1 → XP_017170559.1  MAPK/MAK/MRK overlapping kinase isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  17. XM_017315071.3 → XP_017170560.1  MAPK/MAK/MRK overlapping kinase isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1 → 201
    PKc_like; Protein Kinases, catalytic domain

  18. XM_006515890.5 → XP_006515953.1  MAPK/MAK/MRK overlapping kinase isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:8 → 198
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003950050.2 RNA Sequence

  2. XR_003950051.2 RNA Sequence

  3. XR_003950052.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_184528.1: Suppressed sequence

    Description
    NR_184528.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVS4.1 GenPept UniProtKB/Swiss-Prot:Q9WVS4

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