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Map3k1 mitogen-activated protein kinase kinase kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26401, updated on 16-Apr-2024

Summary

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Official Symbol
Map3k1provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 1provided by MGI
Primary source
MGI:MGI:1346872
See related
Ensembl:ENSMUSG00000021754 AllianceGenome:MGI:1346872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mekk; MEKK1; MAPKKK1
Summary
Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including JNK cascade; eyelid development in camera-type eye; and positive regulation of actin filament polymerization. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 7.6), thymus adult (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Map3k1 in Genome Data Viewer
Location:
13 D2.2; 13 63.36 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111882962..111954803, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111746428..111818269, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene MIER family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E386 Neighboring gene SET domain containing 9, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7284 Neighboring gene STARR-positive B cell enhancer mm9_chr13:112587011-112587312 Neighboring gene STARR-positive B cell enhancer ABC_E1889 Neighboring gene STARR-positive B cell enhancer ABC_E4094 Neighboring gene predicted gene 15327 Neighboring gene predicted gene, 41060 Neighboring gene predicted gene 15325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic Control of MAP3K1 in Eye Development and Sex Differentiation. Wang J, et al. Cells, 2021 Dec 23. PMID 35011600, Free PMC Article
  2. T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion. Suddason T, et al. Cell Rep, 2016 Jan 26. PMID 26774476, Free PMC Article
  3. MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells. Yousaf R, et al. Dis Model Mech, 2015 Dec. PMID 26496772, Free PMC Article
  4. MEK kinase 1: kinase domain deficiency in mice reveals a role in orchestrating the thymus-dependent immunity and TNFR family signaling. Gallagher E. Adv Exp Med Biol, 2011. PMID 21153343
  5. The role of MEKK1 in hypertrophic cardiomyopathy. Konhilas JP, et al. Int Heart J, 2010 Jul. PMID 20716846, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP3K1 regulates female reproductive tract development.
    Title: MAP3K1 regulates female reproductive tract development.
  2. The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.
    Title: The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.
  3. Genetic Control of MAP3K1 in Eye Development and Sex Differentiation.
    Title: Genetic Control of MAP3K1 in Eye Development and Sex Differentiation.
  4. An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.
    Title: An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.
  5. Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1.
    Title: Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1.
  6. Data identify a unique signal crosstalk between Wnt signaling and the MAP3K1-JNK pathway in epithelial morphogenesis.
    Title: Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.
  7. These results reveal the importance of the MEKK1-calponin-3 signaling pathway to cell contractility.
    Title: MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility.
  8. Map3k1 regulates iNKT cell proliferative expansion in response to glycolipid antigen
    Title: T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion.
  9. goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.
    Title: The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells.
  10. These data highlight the crucial role of MAP3K1 in the development and function of the mouse inner ear and hearing.
    Title: MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables sphingolipid binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic mitochondrial changes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within eyelid development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of filamentous actin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 1
Names
MAPK/ERK kinase kinase 1
MEK kinase 1
NP_036075.2
XP_017171005.1
XP_036013944.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011945.3 → NP_036075.2  mitogen-activated protein kinase kinase kinase 1

    See identical proteins and their annotated locations for NP_036075.2

    Status: VALIDATED

    Source sequence(s)
    AC118704
    Consensus CDS
    CCDS26771.1
    UniProtKB/Swiss-Prot
    P53349, Q60831, Q9R0U3, Q9R256
    UniProtKB/TrEMBL
    F8VQ72
    Related
    ENSMUSP00000104890.3, ENSMUST00000109267.9
    Conserved Domains (2) summary
    smart00220
    Location:1224 → 1489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06630
    Location:1223 → 1490
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    111882962..111954803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315516.2 → XP_017171005.1  mitogen-activated protein kinase kinase kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    P53349, Q60831, Q9R0U3, Q9R256
    Conserved Domains (2) summary
    cd06630
    Location:1075 → 1342
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:287 → 342
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

  2. XM_036158051.1 → XP_036013944.1  mitogen-activated protein kinase kinase kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P53349, Q60831, Q9R0U3, Q9R256
    Conserved Domains (2) summary
    cd06630
    Location:1143 → 1410
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:355 → 410
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53349.3 GenPept UniProtKB/Swiss-Prot:P53349

Gene LinkOut

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