U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nav3 neuron navigator 3 [ Mus musculus (house mouse) ]

Gene ID: 260315, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Nav3provided by MGI
Official Full Name
neuron navigator 3provided by MGI
Primary source
MGI:MGI:2183703
See related
Ensembl:ENSMUSG00000020181 AllianceGenome:MGI:2183703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POMFIL1; unc53H3; Pomfil1p; mKIAA0938; 4732483H20Rik; 9630020C08Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of interleukin-2 production; and regulation of microtubule polymerization or depolymerization. Located in nuclear envelope. Is expressed in central nervous system; liver; lung; notochord; and retina layer. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 6.2), cortex adult (RPKM 6.1) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 D1; 10 57.18 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (109517121..110292148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (109681260..110455722, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23041 Neighboring gene STARR-seq mESC enhancer starr_27835 Neighboring gene STARR-seq mESC enhancer starr_27836 Neighboring gene predicted gene, 40757 Neighboring gene STARR-seq mESC enhancer starr_27839 Neighboring gene STARR-seq mESC enhancer starr_27840 Neighboring gene STARR-seq mESC enhancer starr_27841 Neighboring gene STARR-seq mESC enhancer starr_27843 Neighboring gene STARR-seq mESC enhancer starr_27842 Neighboring gene predicted gene, 47340 Neighboring gene STARR-seq mESC enhancer starr_27844 Neighboring gene STARR-seq mESC enhancer starr_27845 Neighboring gene STARR-seq mESC enhancer starr_27846 Neighboring gene RIKEN cDNA 9230102K24 gene Neighboring gene STARR-seq mESC enhancer starr_27847 Neighboring gene STARR-seq mESC enhancer starr_27848 Neighboring gene predicted gene, 36751

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Peeters PJ, et al. Brain Res Dev Brain Res, 2004 Jun 21. PMID 15158073
  2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Coy JF, et al. Gene, 2002 May 15. PMID 12062803
  3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule end ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neuron navigator 3
Names
pore membrane and/or filament-interacting-like protein 1
steerin 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081035.2 → NP_001074504.1  neuron navigator 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100120, AC122011, AC129336
    Consensus CDS
    CCDS36054.1
    UniProtKB/TrEMBL
    E9QMF5
    Related
    ENSMUSP00000032719.8, ENSMUST00000032719.15
    Conserved Domains (5) summary
    cd00009
    Location:2033 → 2113
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:2030 → 2150
    AAA; ATPases associated with a variety of cellular activities
    cd00014
    Location:81 → 182
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15898
    Location:1775 → 1838
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl21455
    Location:2017 → 2047
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001368815.1 → NP_001355744.1  neuron navigator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100120, AC122011, AC129336
    UniProtKB/Swiss-Prot
    Q80TN7
    Conserved Domains (6) summary
    smart00382
    Location:2023 → 2143
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:979 → 1294
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00014
    Location:81 → 182
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    TIGR04211
    Location:1573 → 1649
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204 → 582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:1768 → 1831
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    109517121..110292148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155787.1 → XP_036011680.1  neuron navigator 3 isoform X4

    UniProtKB/TrEMBL
    A0A668KM70
    Conserved Domains (5) summary
    smart00382
    Location:1973 → 2093
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:922 → 1237
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1519 → 1779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:147 → 525
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24 → 126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

  2. XM_006513680.4 → XP_006513743.1  neuron navigator 3 isoform X8

    Conserved Domains (7) summary
    smart00382
    Location:1853 → 1973
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:979 → 1297
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1399 → 1659
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:1396 → 1472
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204 → 582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81 → 182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:1607 → 1661
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  3. XM_006513679.4 → XP_006513742.1  neuron navigator 3 isoform X7

    Conserved Domains (7) summary
    smart00382
    Location:1867 → 1987
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:979 → 1311
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1413 → 1673
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:1410 → 1486
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204 → 582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81 → 182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:1621 → 1675
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  4. XM_006513676.4 → XP_006513739.1  neuron navigator 3 isoform X1

    Conserved Domains (7) summary
    smart00382
    Location:2016 → 2136
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:979 → 1294
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1562 → 1822
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:1559 → 1635
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204 → 582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81 → 182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:1770 → 1824
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  5. XM_006513677.4 → XP_006513740.1  neuron navigator 3 isoform X3

    Conserved Domains (6) summary
    smart00382
    Location:2007 → 2127
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:956 → 1271
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1553 → 1813
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:1550 → 1626
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:262 → 559
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81 → 182
    CH; Calponin homology (CH) domain

  6. XM_017313948.3 → XP_017169437.1  neuron navigator 3 isoform X10

    UniProtKB/TrEMBL
    A0A571BDN3
    Related
    ENSMUSP00000158790.2, ENSMUST00000238286.2
    Conserved Domains (6) summary
    smart00382
    Location:1515 → 1635
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:478 → 793
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02169
    Location:1050 → 1321
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR04211
    Location:1058 → 1134
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:659 → 996
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:1269 → 1323
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  7. XM_006513681.5 → XP_006513744.1  neuron navigator 3 isoform X9

    UniProtKB/TrEMBL
    A0A571BDN3
    Conserved Domains (6) summary
    smart00382
    Location:1529 → 1649
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:478 → 793
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02169
    Location:1064 → 1335
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR04211
    Location:1072 → 1148
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:659 → 1010
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:1283 → 1337
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  8. XM_036155788.1 → XP_036011681.1  neuron navigator 3 isoform X5

    Conserved Domains (5) summary
    smart00382
    Location:1950 → 2070
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:899 → 1214
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1496 → 1756
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:205 → 502
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24 → 126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

  9. XM_017313946.3 → XP_017169435.1  neuron navigator 3 isoform X4

    UniProtKB/TrEMBL
    A0A668KM70
    Related
    ENSMUSP00000159239.2, ENSMUST00000239301.2
    Conserved Domains (5) summary
    smart00382
    Location:1973 → 2093
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:922 → 1237
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1519 → 1779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:147 → 525
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24 → 126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

  10. XM_017313945.2 → XP_017169434.1  neuron navigator 3 isoform X2

    Conserved Domains (6) summary
    smart00382
    Location:2009 → 2129
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:979 → 1294
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR04211
    Location:1559 → 1635
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204 → 582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81 → 182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:1763 → 1817
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  11. XM_036155789.1 → XP_036011682.1  neuron navigator 3 isoform X6

    Conserved Domains (5) summary
    smart00382
    Location:1893 → 2013
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:842 → 1157
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:1439 → 1699
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:67 → 445
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00030
    Location:1 → 46
    CH_SF; calponin homology (CH) domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177797.2: Suppressed sequence

    Description
    NM_177797.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TN7.2 GenPept UniProtKB/Swiss-Prot:Q80TN7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous