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OSBPL3 oxysterol binding protein like 3 [ Homo sapiens (human) ]

Gene ID: 26031, updated on 11-Apr-2024

Summary

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Official Symbol
OSBPL3provided by HGNC
Official Full Name
oxysterol binding protein like 3provided by HGNC
Primary source
HGNC:HGNC:16370
See related
Ensembl:ENSG00000070882 MIM:606732; AllianceGenome:HGNC:16370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP3; ORP-3; OSBP3
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See OSBPL3 in Genome Data Viewer
Location:
7p15.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (24796537..24981845, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (24934545..25120219, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (24836156..25019797, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25748 Neighboring gene SUMO2 pseudogene 14 Neighboring gene protein associated with LIN7 2, MAGUK p55 family member Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:24725223-24725819 Neighboring gene Sharpr-MPRA regulatory region 3197 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24744538-24744707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24757299-24757886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24764003-24764686 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24765371-24766054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24766055-24766736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25753 Neighboring gene Sharpr-MPRA regulatory region 13058 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18020 Neighboring gene gasdermin E Neighboring gene Sharpr-MPRA regulatory region 12520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25756 Neighboring gene MPRA-validated peak6442 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24834867-24835372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24834361-24834866 Neighboring gene NANOG hESC enhancer GRCh37_chr7:24841903-24842404 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:24865671-24866870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25760 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24990225-24990724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:25010975-25011630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:25068437-25068938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:25098668-25099168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25767 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:25163804-25164348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:25164349-25164892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25768 Neighboring gene uncharacterized LOC124901603 Neighboring gene uncharacterized LOC124901602 Neighboring gene sperm microtubule inner protein 4 Neighboring gene cytochrome c, somatic

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer. Hu Q, et al. Sci Rep, 2021 Sep 28. PMID 34584127, Free PMC Article
  2. Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins. Tong J, et al. PLoS One, 2021. PMID 33857182, Free PMC Article
  3. Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. Xu P, et al. Int J Mol Sci, 2020 Aug 16. PMID 32824360, Free PMC Article
  4. The crystal structure of ORP3 reveals the conservative PI4P binding pattern. Dong X, et al. Biochem Biophys Res Commun, 2020 Sep 3. PMID 32819557
  5. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor. Njeru SN, et al. Oncogene, 2020 Feb. PMID 31659255

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
    Title: Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
  2. Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.
    Title: Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.
  3. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease.
    Title: Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.
  4. The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.
    Title: The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.
  5. Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.
    Title: Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.
  6. Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
    Title: Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
  7. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
    Title: Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
  8. Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer.
    Title: Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer.
  9. The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
    Title: The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
  10. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
    Title: Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of oxysterol binding protein-like 3 (OSBPL3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0704, MGC21526, DKFZp667P1518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid biosynthetic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium tip IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
oxysterol-binding protein-related protein 3
Names
OSBP-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015550.4 → NP_056365.1  oxysterol-binding protein-related protein 3 isoform a

    See identical proteins and their annotated locations for NP_056365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Isoform a contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1a.
    Source sequence(s)
    AB014604, AC003093, AY008372, DR003143
    Consensus CDS
    CCDS5390.1
    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
    Related
    ENSP00000315410.2, ENST00000313367.7
    Conserved Domains (2) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:527 → 871
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_145320.2 → NP_663160.1  oxysterol-binding protein-related protein 3 isoform b

    See identical proteins and their annotated locations for NP_663160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a. Isoform b contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1b.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491782, AW241639, AY008372
    Consensus CDS
    CCDS5391.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000379708.1, ENST00000396431.5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:496 → 830
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_145321.2 → NP_663161.1  oxysterol-binding protein-related protein 3 isoform c

    See identical proteins and their annotated locations for NP_663161.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (c) compared to isoform a. Isoform c contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1c.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491783, AW241639, AY008372
    Consensus CDS
    CCDS5392.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000379706.1, ENST00000396429.5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:491 → 825
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_145322.2 → NP_663162.1  oxysterol-binding protein-related protein 3 isoform d

    See identical proteins and their annotated locations for NP_663162.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1, resulting in a shorter isoform (d) compared to isoform a. Isoform d contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1d.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491784, AW241639, AY008372
    Consensus CDS
    CCDS47564.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000386953.1, ENST00000409069.5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:460 → 794
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. NR_104111.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491785, AW241639, AY008372

  2. NR_104112.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491786, AW241639, AY008372

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    24796537..24981845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420146.1 → XP_047276102.1  oxysterol-binding protein-related protein 3 isoform X5

  2. XM_047420134.1 → XP_047276090.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  3. XM_047420131.1 → XP_047276087.1  oxysterol-binding protein-related protein 3 isoform X1

  4. XM_047420148.1 → XP_047276104.1  oxysterol-binding protein-related protein 3 isoform X6

  5. XM_047420145.1 → XP_047276101.1  oxysterol-binding protein-related protein 3 isoform X5

  6. XM_047420137.1 → XP_047276093.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  7. XM_047420135.1 → XP_047276091.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  8. XM_006715683.4 → XP_006715746.1  oxysterol-binding protein-related protein 3 isoform X7

    See identical proteins and their annotated locations for XP_006715746.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:460 → 794
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_006715681.4 → XP_006715744.1  oxysterol-binding protein-related protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006715744.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:496 → 830
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_047420139.1 → XP_047276095.1  oxysterol-binding protein-related protein 3 isoform X3

  11. XM_006715682.4 → XP_006715745.1  oxysterol-binding protein-related protein 3 isoform X6

    See identical proteins and their annotated locations for XP_006715745.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52 → 142
    PH; PH domain
    pfam01237
    Location:491 → 825
    Oxysterol_BP; Oxysterol-binding protein

  12. XM_047420142.1 → XP_047276098.1  oxysterol-binding protein-related protein 3 isoform X4

  13. XM_047420129.1 → XP_047276085.1  oxysterol-binding protein-related protein 3 isoform X1

  14. XM_047420136.1 → XP_047276092.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  15. XM_047420149.1 → XP_047276105.1  oxysterol-binding protein-related protein 3 isoform X6

  16. XM_047420138.1 → XP_047276094.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  17. XM_047420143.1 → XP_047276099.1  oxysterol-binding protein-related protein 3 isoform X5

  18. XM_047420140.1 → XP_047276096.1  oxysterol-binding protein-related protein 3 isoform X3

  19. XM_047420150.1 → XP_047276106.1  oxysterol-binding protein-related protein 3 isoform X6

  20. XM_005249698.4 → XP_005249755.1  oxysterol-binding protein-related protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005249755.1

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
    Conserved Domains (2) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:527 → 871
    Oxysterol_BP; Oxysterol-binding protein

  21. XM_047420132.1 → XP_047276088.1  oxysterol-binding protein-related protein 3 isoform X1

  22. XM_047420151.1 → XP_047276107.1  oxysterol-binding protein-related protein 3 isoform X7

  23. XM_047420144.1 → XP_047276100.1  oxysterol-binding protein-related protein 3 isoform X5

  24. XM_047420141.1 → XP_047276097.1  oxysterol-binding protein-related protein 3 isoform X3

  25. XM_047420147.1 → XP_047276103.1  oxysterol-binding protein-related protein 3 isoform X6

  26. XM_011515258.3 → XP_011513560.1  oxysterol-binding protein-related protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011513560.1

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6
    Conserved Domains (2) summary
    cd13287
    Location:31 → 153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:527 → 871
    Oxysterol_BP; Oxysterol-binding protein

  27. XM_047420130.1 → XP_047276086.1  oxysterol-binding protein-related protein 3 isoform X1

  28. XM_047420133.1 → XP_047276089.1  oxysterol-binding protein-related protein 3 isoform X1

  29. XM_047420153.1 → XP_047276109.1  oxysterol-binding protein-related protein 3 isoform X9

  30. XM_047420152.1 → XP_047276108.1  oxysterol-binding protein-related protein 3 isoform X8

RNA

  1. XR_007060001.1 RNA Sequence

  2. XR_007060007.1 RNA Sequence

  3. XR_007060005.1 RNA Sequence

  4. XR_007060006.1 RNA Sequence

  5. XR_007060004.1 RNA Sequence

  6. XR_007060002.1 RNA Sequence

  7. XR_007060003.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    24934545..25120219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357787.1 → XP_054213762.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  2. XM_054357801.1 → XP_054213776.1  oxysterol-binding protein-related protein 3 isoform X5

  3. XM_054357802.1 → XP_054213777.1  oxysterol-binding protein-related protein 3 isoform X5

  4. XM_054357805.1 → XP_054213780.1  oxysterol-binding protein-related protein 3 isoform X6

  5. XM_054357792.1 → XP_054213767.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  6. XM_054357784.1 → XP_054213759.1  oxysterol-binding protein-related protein 3 isoform X1

  7. XM_054357790.1 → XP_054213765.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  8. XM_054357808.1 → XP_054213783.1  oxysterol-binding protein-related protein 3 isoform X7

  9. XM_054357798.1 → XP_054213773.1  oxysterol-binding protein-related protein 3 isoform X5

  10. XM_054357794.1 → XP_054213769.1  oxysterol-binding protein-related protein 3 isoform X3

  11. XM_054357803.1 → XP_054213778.1  oxysterol-binding protein-related protein 3 isoform X6

  12. XM_054357797.1 → XP_054213772.1  oxysterol-binding protein-related protein 3 isoform X4

  13. XM_054357782.1 → XP_054213757.1  oxysterol-binding protein-related protein 3 isoform X1

  14. XM_054357791.1 → XP_054213766.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  15. XM_054357806.1 → XP_054213781.1  oxysterol-binding protein-related protein 3 isoform X6

  16. XM_054357793.1 → XP_054213768.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  17. XM_054357786.1 → XP_054213761.1  oxysterol-binding protein-related protein 3 isoform X1

  18. XM_054357796.1 → XP_054213771.1  oxysterol-binding protein-related protein 3 isoform X3

  19. XM_054357807.1 → XP_054213782.1  oxysterol-binding protein-related protein 3 isoform X6

  20. XM_054357799.1 → XP_054213774.1  oxysterol-binding protein-related protein 3 isoform X5

  21. XM_054357788.1 → XP_054213763.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  22. XM_054357785.1 → XP_054213760.1  oxysterol-binding protein-related protein 3 isoform X1

  23. XM_054357809.1 → XP_054213784.1  oxysterol-binding protein-related protein 3 isoform X7

  24. XM_054357800.1 → XP_054213775.1  oxysterol-binding protein-related protein 3 isoform X5

  25. XM_054357795.1 → XP_054213770.1  oxysterol-binding protein-related protein 3 isoform X3

  26. XM_054357804.1 → XP_054213779.1  oxysterol-binding protein-related protein 3 isoform X6

  27. XM_054357789.1 → XP_054213764.1  oxysterol-binding protein-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    A4D167, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9H4L5, Q9UED6

  28. XM_054357783.1 → XP_054213758.1  oxysterol-binding protein-related protein 3 isoform X1

  29. XM_054357811.1 → XP_054213786.1  oxysterol-binding protein-related protein 3 isoform X9

  30. XM_054357810.1 → XP_054213785.1  oxysterol-binding protein-related protein 3 isoform X8

RNA

  1. XR_008487556.1 RNA Sequence

  2. XR_008487562.1 RNA Sequence

  3. XR_008487560.1 RNA Sequence

  4. XR_008487561.1 RNA Sequence

  5. XR_008487559.1 RNA Sequence

  6. XR_008487557.1 RNA Sequence

  7. XR_008487558.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145323.1: Suppressed sequence

    Description
    NM_145323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.

  2. NM_145324.1: Suppressed sequence

    Description
    NM_145324.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H4L5.1 GenPept UniProtKB/Swiss-Prot:Q9H4L5

Gene LinkOut

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