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Ambp alpha-1-microglobulin/bikunin precursor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25377, updated on 27-Apr-2024

Summary

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Official Symbol
Ambpprovided by RGD
Official Full Name
alpha-1-microglobulin/bikunin precursorprovided by RGD
Primary source
RGD:2102
See related
Ensembl:ENSRNOG00000006889 AllianceGenome:RGD:2102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UTI
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in protein catabolic process. Located in cell surface; extracellular space; and intracellular membrane-bounded organelle. Biomarker of calcium oxalate nephrolithiasis. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 18007.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
5q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81583621..81593938, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76568094..76578416, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78975690..78986021, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487070 Neighboring gene zinc finger protein 618 Neighboring gene kinesin family member 12 Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Evaluation of inflammatory and renal injury markers in youngest children with pyelonephritis]. Puczko-Michalczuk A, et al. Pol Merkur Lekarski, 2008 Dec. PMID 19205372
  2. Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients. Vyssoulis GP, et al. Am J Hypertens, 2007 Sep. PMID 17765145
  3. Urine protein markers distinguish stone-forming from non-stone-forming relatives of calcium stone formers. Bergsland KJ, et al. Am J Physiol Renal Physiol, 2006 Sep. PMID 16622176
  4. Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes. Ito K, et al. Injury, 2005 Mar. PMID 15710155
  5. Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells. Grewal JS, et al. Biochem J, 2005 May 1. PMID 15533056, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables IgA binding IEA
Inferred from Electronic Annotation
more info
  
enables IgA binding ISO
Inferred from Sequence Orthology
more info
  
enables IgA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
  
enables antioxidant activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
  
enables chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables collagen fibril binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen fibril binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular oxidant detoxification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytochrome c metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cytochrome c metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hemoglobin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hemoglobin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in matrix side of mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein AMBP
Names
Alpha-1 microglobulin/bikunin
alpha 1 microglobulin/bikunin
ulinastatin
urinary trypsin inhibitor
NP_037033.1
XP_008761981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429333.1 → NP_001416262.1  protein AMBP isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_012901.3 → NP_037033.1  protein AMBP isoform 2 precursor

    See identical proteins and their annotated locations for NP_037033.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P19603, Q63336, Q64240
    UniProtKB/TrEMBL
    A0A8I5ZUK6, A6J7X0
    Related
    ENSRNOP00000082240.1, ENSRNOT00000104037.1
    Conserved Domains (2) summary
    pfam00014
    Location:230 → 281
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00061
    Location:41 → 185
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    81583621..81593938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763759.4 → XP_008761981.1  protein AMBP isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUK6, A0A8L2Q3T3
    Related
    ENSRNOP00000009248.3
    Conserved Domains (2) summary
    pfam00014
    Location:230 → 281
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00061
    Location:41 → 185
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64240.1 GenPept UniProtKB/Swiss-Prot:Q64240

Gene LinkOut

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