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Arsb arylsulfatase B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25227, updated on 5-Mar-2024

Summary

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Official Symbol
Arsbprovided by RGD
Official Full Name
arylsulfatase Bprovided by RGD
Primary source
RGD:2158
See related
Ensembl:ENSRNOG00000011150 AllianceGenome:RGD:2158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables sulfuric ester hydrolase activity. Involved in several processes, including positive regulation of neuron projection development; response to estrogen; and response to methylmercury. Located in several cellular components, including Golgi apparatus; lysosome; and rough endoplasmic reticulum. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 330.0), Adrenal (RPKM 238.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (26736395..26895682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (25002210..25162675)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (23385154..23543028)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene betaine-homocysteine S-methyltransferase 2 Neighboring gene dimethylglycine dehydrogenase Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC120100667 Neighboring gene LHFPL tetraspan subfamily member 2 Neighboring gene SNRPN upstream open reading frame, pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol. Zhang X, et al. Glia, 2014 Feb. PMID 24311516, Free PMC Article
  2. Cytochemical localization of arylsulfatase B in rat basophils and mast cells. Bentfeld-Barker ME, et al. J Histochem Cytochem, 1980 Oct. PMID 7419898
  3. Ultrastructural localization of arylsulfatase B in mitochondria of epithelial cells of the proximal convoluted tubules of the rat kidney. Makita T, et al. Experientia, 1971 Feb 15. PMID 5544743
  4. Isolation and characterization of rat hepatic ascorbic acid-2-sulfatases. Thompson DB, et al. Enzyme, 1987. PMID 2884099
  5. Characterization of liver lysosomal enzyme activity in hepatocytes, Kupffer and endothelial cells during aging: effect of dietary restriction. Ferland G, et al. Mech Ageing Dev, 1990 Nov. PMID 2290353

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylgalactosamine-4-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acetylgalactosamine-4-sulfatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables N-acetylgalactosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior head development ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in colon epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in colon epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dermatan sulfate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to methylmercury IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to pH IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arylsulfatase B
Names
ASB
Arylsulfatase B (MPS VI)
G4S
N-acetylgalactosamine-4-sulfatase
NP_254278.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033443.1 → NP_254278.1  arylsulfatase B precursor

    See identical proteins and their annotated locations for NP_254278.1

    Status: VALIDATED

    Source sequence(s)
    AI071950, CF113828, CK482953, D49434
    UniProtKB/Swiss-Prot
    P50430, Q32KK1
    UniProtKB/TrEMBL
    A6I4W1, B4F7E2
    Related
    ENSRNOP00000014860.5, ENSRNOT00000014860.7
    Conserved Domains (2) summary
    COG3119
    Location:36 → 484
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16029
    Location:40 → 483
    4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    26736395..26895682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005500242.2 RNA Sequence

  2. XR_005500243.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50430.2 GenPept UniProtKB/Swiss-Prot:P50430

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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