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Naxe NAD(P)HX epimerase [ Mus musculus (house mouse) ]

Gene ID: 246703, updated on 5-Mar-2024

Summary

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Official Symbol
Naxeprovided by MGI
Official Full Name
NAD(P)HX epimeraseprovided by MGI
Primary source
MGI:MGI:2180167
See related
Ensembl:ENSMUSG00000028070 AllianceGenome:MGI:2180167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIBP; AI-BP; ESTM37; Apoa1bp; Apoa1ip
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Predicted to act upstream of or within lipid transport. Located in several cellular components, including cell body; extracellular space; and mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and skeletal muscle tissue. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 55.9), adrenal adult (RPKM 49.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Naxe in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87963827..87965851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88056520..88058542, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19439 Neighboring gene STARR-positive B cell enhancer ABC_E10191 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E10192 Neighboring gene IQ motif containing GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration. Kim JD, et al. Cells, 2022 Nov 17. PMID 36429071, Free PMC Article
  2. Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization. Zhang Z, et al. Invest Ophthalmol Vis Sci, 2022 Nov 1. PMID 36318195, Free PMC Article
  3. Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization. Duan M, et al. Cell Commun Signal, 2022 May 7. PMID 35525979, Free PMC Article
  4. Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice. Kim JD, et al. PLoS One, 2021. PMID 33793635, Free PMC Article
  5. AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Choi SH, et al. Redox Biol, 2020 Oct. PMID 32896719, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons.
    Title: AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons.
  2. AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration.
    Title: AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration.
  3. Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization.
    Title: Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization.
  4. These results indicate that the combination of APOA-I and AIBP has an obvious anticancer effect on colorectal cancer by promoting cholesterol efflux.
    Title: AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux.
  5. These findings demonstrate a mechanism by which AIBP regulates neuroinflammation.
    Title: Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.
  6. data demonstrate that AIBP confers protection against diet-induced metabolic abnormalities and atherosclerosis
    Title: AIBP protects against metabolic abnormalities and atherosclerosis.
  7. Loss of Apoa1bp increased vascular density and facilitated the recovery of blood vessel perfusion function in a hindlimb ischemia model.
    Title: AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.
  8. The Aibp gene encodes two different proteins, both targeted to the mitochondria (mAIBP) and cytosol (cAIBP) confirming the presence of dehydratase and epimerase in the cytosol and mitochondria.
    Title: Occurrence and subcellular distribution of the NADPHX repair system in mammals.
  9. AI-BP plays an important role in capacitation possibly providing a link between protein phosphorylation and cholesterol efflux.
    Title: Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADHX epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPHX epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane raft distribution ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nicotinamide nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
NAD(P)H-hydrate epimerase
Names
apoA-I binding protein
apolipoprotein A-I binding protein
apolipoprotein A-I interacting protein
NP_001396696.1
NP_001396697.1
NP_001396699.1
NP_001396700.1
NP_001396702.1
NP_001396703.1
NP_001396704.1
NP_001396705.1
NP_001396706.1
NP_001396707.1
NP_001396708.1
NP_001396709.1
NP_659146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409767.1 → NP_001396696.1  NAD(P)H-hydrate epimerase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC137525

  2. NM_001409768.1 → NP_001396697.1  NAD(P)H-hydrate epimerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137525

  3. NM_001409770.1 → NP_001396699.1  NAD(P)H-hydrate epimerase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525

  4. NM_001409771.1 → NP_001396700.1  NAD(P)H-hydrate epimerase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC137525

  5. NM_001409773.1 → NP_001396702.1  NAD(P)H-hydrate epimerase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC137525

  6. NM_001409774.1 → NP_001396703.1  NAD(P)H-hydrate epimerase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC137525

  7. NM_001409775.1 → NP_001396704.1  NAD(P)H-hydrate epimerase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC137525

  8. NM_001409776.1 → NP_001396705.1  NAD(P)H-hydrate epimerase isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525

  9. NM_001409777.1 → NP_001396706.1  NAD(P)H-hydrate epimerase isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525

  10. NM_001409778.1 → NP_001396707.1  NAD(P)H-hydrate epimerase isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137525

  11. NM_001409779.1 → NP_001396708.1  NAD(P)H-hydrate epimerase isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC137525

  12. NM_001409780.1 → NP_001396709.1  NAD(P)H-hydrate epimerase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC137525

  13. NM_144897.4 → NP_659146.1  NAD(P)H-hydrate epimerase isoform 2 precursor

    See identical proteins and their annotated locations for NP_659146.1

    Status: VALIDATED

    Source sequence(s)
    AC137525
    Consensus CDS
    CCDS17464.1
    UniProtKB/Swiss-Prot
    Q8K4Z3
    Related
    ENSMUSP00000029708.7, ENSMUST00000029708.8
    Conserved Domains (1) summary
    cl00318
    Location:46 → 281
    YjeF_N; YjeF-related protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87963827..87965851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941327.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4Z3.1 GenPept UniProtKB/Swiss-Prot:Q8K4Z3

Gene LinkOut

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