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Npat nuclear protein in the AT region [ Mus musculus (house mouse) ]

Gene ID: 244879, updated on 21-Apr-2024

Summary

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Official Symbol
Npatprovided by MGI
Official Full Name
nuclear protein in the AT regionprovided by MGI
Primary source
MGI:MGI:107605
See related
Ensembl:ENSMUSG00000033054 AllianceGenome:MGI:107605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6820401K01
Summary
Predicted to enable protein C-terminus binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within in utero embryonic development. Predicted to be located in Cajal body; Gemini of coiled bodies; and cytoplasm. Predicted to be active in nucleus. Is expressed in inner cell mass. Orthologous to human NPAT (nuclear protein, coactivator of histone transcription). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.3), placenta adult (RPKM 4.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53448347..53486867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53536889..53575627)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930550C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897 Neighboring gene STARR-seq mESC enhancer starr_24146 Neighboring gene acetyl-Coenzyme A acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1384 Neighboring gene cullin 5 Neighboring gene predicted gene, 22304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development. Cui Z, et al. J Immunol, 2022 Sep 1. PMID 35922064
  2. Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrest. Di Fruscio M, et al. Mol Cell Biol, 1997 Jul. PMID 9199343, Free PMC Article
  3. The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection. Chen C, et al. PLoS One, 2021. PMID 34197485, Free PMC Article
  4. Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition. Xie RL, et al. Gene, 2007 Nov 1. PMID 17826007, Free PMC Article
  5. NPAT expression is regulated by E2F and is essential for cell cycle progression. Gao G, et al. Mol Cell Biol, 2003 Apr. PMID 12665581, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
    Title: NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
  2. Our data indicates that the function of Npat-dependent Sertoli cells is essential at multiple steps in testis development, and this study also identifies Sertoli cells as a major regulator of germ cell development, which are required to maintain a local growth niche to repress premature mitosis and meiosis of gonocytes.
    Title: Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.
  3. Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
    Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
  4. NPAT links E2F to the activation of S-phase-specific histone gene transcription.
    Title: NPAT expression is regulated by E2F and is essential for cell cycle progression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Gemini of coiled bodies ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein NPAT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081152.2 → NP_001074621.1  protein NPAT isoform 1

    See identical proteins and their annotated locations for NP_001074621.1

    Status: VALIDATED

    Source sequence(s)
    AC156640
    Consensus CDS
    CCDS40637.1
    UniProtKB/Swiss-Prot
    Q8BMA5, Q8BWA9, Q8BY06
    Related
    ENSMUSP00000048709.8, ENSMUST00000035850.8
    Conserved Domains (1) summary
    pfam15712
    Location:755 → 1420
    NPAT_C; NPAT C terminus

  2. NM_001409956.1 → NP_001396885.1  protein NPAT isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156640

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    53448347..53486867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242531.3 → XP_011240833.1  protein NPAT isoform X2

    Conserved Domains (1) summary
    pfam15712
    Location:447 → 1113
    NPAT_C; NPAT C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178905.2: Suppressed sequence

    Description
    NM_178905.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMA5.2 GenPept UniProtKB/Swiss-Prot:Q8BMA5

Gene LinkOut

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