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Bnc2 basonuclin zinc finger protein 2 [ Mus musculus (house mouse) ]

Gene ID: 242509, updated on 25-Apr-2024

Summary

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Official Symbol
Bnc2provided by MGI
Official Full Name
basonuclin zinc finger protein 2provided by MGI
Primary source
MGI:MGI:2443805
See related
Ensembl:ENSMUSG00000028487 AllianceGenome:MGI:2443805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5031434M05Rik; 8430420F16Rik
Summary
Enables DNA binding activity. Acts upstream of or within several processes, including endochondral bone growth; roof of mouth development; and tongue development. Located in nucleus. Is expressed in several structures, including genitourinary system; jaw; nervous system; nose; and skin. Orthologous to human BNC2 (basonuclin 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 2.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C3- C4; 4 39.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (84185041..84593236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (84266804..84676029, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42310 Neighboring gene predicted gene, 33597 Neighboring gene STARR-seq mESC enhancer starr_10655 Neighboring gene STARR-seq mESC enhancer starr_10656 Neighboring gene STARR-seq mESC enhancer starr_10659 Neighboring gene STARR-seq mESC enhancer starr_10660 Neighboring gene STARR-seq mESC enhancer starr_10664 Neighboring gene STARR-seq mESC enhancer starr_10666 Neighboring gene STARR-seq mESC enhancer starr_10669 Neighboring gene serine incorporator 3 pseudogene Neighboring gene predicted gene 12415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis. Chen Y, et al. Brain Behav, 2023 May. PMID 36960892, Free PMC Article
  2. Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis. Bobowski-Gerard M, et al. Nat Commun, 2022 Sep 10. PMID 36088459, Free PMC Article
  3. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development. Bhoj EJ, et al. Eur J Hum Genet, 2011 May. PMID 21368915, Free PMC Article
  4. Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins. Vanhoutteghem A, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706529, Free PMC Article
  5. Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions. Vanhoutteghem A, et al. Proc Natl Acad Sci U S A, 2006 Aug 15. PMID 16891417, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis.
    Title: Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis.
  2. BNC1 cannot substitute for BNC2.
    Title: The importance of basonuclin 2 in adult mice and its relation to basonuclin 1.
  3. BNC2 is a major regulator of male germ stem cells, which is required for repression of meiosis and mitosis in prospermatogonia, and for meiosis progression during spermatogenesis.
    Title: The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells.
  4. Bnc2(-/-) mice of both sexes displayed a high frequency of distal urethral defects; heterozygotes showed similar defects with reduced penetrance.
    Title: Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.
  5. Results show that basonuclin 2 is essential for the multiplication of craniofacial mesenchymal cells during embryogenesis.
    Title: Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins.
  6. the extreme conservation of the basonuclin 2 amino acid sequence across vertebrates suggests that basonuclin 2 serves an important function, presumably as a regulatory protein of DNA transcription
    Title: Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin.
  7. gene expression profiling; structural and functional similarities with Basonuclin 1 suggest that Basonuclin2 may play an analogous function in germ cells and skin keratinocytes
    Title: Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes.
  8. Data show that basonuclin (Bn)2 but not bn1 colocalizes with SC35 in nuclear speckles, and may have a function in nuclear processing of mRNA.
    Title: Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124423, MGC124424

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables rDNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endochondral bone growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesenchyme development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tongue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein basonuclin-2
Names
basonuclin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369081.2 → NP_001356010.1  zinc finger protein basonuclin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL772137, AL772261, AL805919, BX004826
    UniProtKB/Swiss-Prot
    H3BIU0, Q6T3A4, Q8BMQ3
    Conserved Domains (2) summary
    sd00017
    Location:1044 → 1065
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:842 → 863
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001369082.2 → NP_001356011.1  zinc finger protein basonuclin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772137, AL772261, AL805919, BX004826
    UniProtKB/TrEMBL
    Q2TBA5
    Conserved Domains (2) summary
    sd00017
    Location:977 → 998
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:775 → 796
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001369083.2 → NP_001356012.1  zinc finger protein basonuclin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772137, AL772261, AL805919, BX004826
    Consensus CDS
    CCDS89773.1
    UniProtKB/Swiss-Prot
    H3BIU0, Q6T3A4, Q8BMQ3
    UniProtKB/TrEMBL
    H3BIU2
    Related
    ENSMUSP00000102816.3, ENSMUST00000107198.9
    Conserved Domains (2) summary
    sd00017
    Location:1037 → 1058
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:835 → 856
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001369084.2 → NP_001356013.1  zinc finger protein basonuclin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL772137, AL772261, AL805919, BX004826
    UniProtKB/TrEMBL
    Q2TBA4, Q2TBA5
    Conserved Domains (1) summary
    sd00017
    Location:959 → 980
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_172870.6 → NP_766458.3  zinc finger protein basonuclin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772137, AL772261, AL805919, BX004826
    Consensus CDS
    CCDS18301.2
    UniProtKB/TrEMBL
    Q2TBA5
    Related
    ENSMUSP00000135375.2, ENSMUST00000176691.8
    Conserved Domains (1) summary
    sd00017
    Location:970 → 991
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    84185041..84593236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMQ3.3 GenPept UniProtKB/Swiss-Prot:Q8BMQ3

Gene LinkOut

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