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Frmd3 FERM domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 242506, updated on 11-Apr-2024

Summary

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Official Symbol
Frmd3provided by MGI
Official Full Name
FERM domain containing 3provided by MGI
Primary source
MGI:MGI:2442466
See related
Ensembl:ENSMUSG00000049122 AllianceGenome:MGI:2442466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4.1O; P410; EPB41L4O; 9430066I12Rik
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoskeleton. Orthologous to human FRMD3 (FERM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 2.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C3; 4 36.06 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (73931454..74120451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (74013228..74202214)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310002L09 gene Neighboring gene Myb/SANT DNA binding domain containing 5 family member 9 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10543 Neighboring gene STARR-seq mESC enhancer starr_10544 Neighboring gene zinc finger protein 384 pseudogene Neighboring gene lysine (K)-specific demethylase 4C Neighboring gene STARR-positive B cell enhancer mm9_chr4:73965324-73965624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163732.1 → NP_001157204.1  FERM domain-containing protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different exon for its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK034956, AK079349
    Consensus CDS
    CCDS51212.1
    UniProtKB/Swiss-Prot
    Q8BHD4
    UniProtKB/TrEMBL
    Q8BV94
    Related
    ENSMUSP00000095615.3, ENSMUST00000098006.9
    Conserved Domains (5) summary
    smart00295
    Location:33 → 225
    B41; Band 4.1 homologues
    pfam00373
    Location:117 → 225
    FERM_M; FERM central domain
    pfam08736
    Location:323 → 357
    FA; FERM adjacent (FA)
    pfam09379
    Location:36 → 99
    FERM_N; FERM N-terminal domain
    cl17171
    Location:206 → 309
    PH-like; Pleckstrin homology-like domain

  2. NM_172869.5 → NP_766457.1  FERM domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_766457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL844607, BX088570, BX957282
    Consensus CDS
    CCDS38789.1
    UniProtKB/Swiss-Prot
    A2BEJ6, Q3UF23, Q5SPU0, Q5SPU1, Q8BHD4, Q8C045
    Related
    ENSMUSP00000081514.6, ENSMUST00000084474.6
    Conserved Domains (5) summary
    smart00295
    Location:33 → 225
    B41; Band 4.1 homologues
    pfam00373
    Location:117 → 225
    FERM_M; FERM central domain
    pfam08736
    Location:323 → 357
    FA; FERM adjacent (FA)
    pfam09379
    Location:36 → 99
    FERM_N; FERM N-terminal domain
    cl17171
    Location:206 → 309
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    73931454..74120451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253548.2 → XP_030109408.1  FERM domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    pfam08736
    Location:74 → 119
    FA; FERM adjacent (FA)
    cl17171
    Location:11 → 60
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHD4.1 GenPept UniProtKB/Swiss-Prot:Q8BHD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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