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Zfp462 zinc finger protein 462 [ Mus musculus (house mouse) ]

Gene ID: 242466, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp462provided by MGI
Official Full Name
zinc finger protein 462provided by MGI
Primary source
MGI:MGI:107690
See related
Ensembl:ENSMUSG00000060206 AllianceGenome:MGI:107690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gt4-2; Zfpip; Znf462; 6030417H05; 9430078C22Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within chromatin organization; negative regulation of DNA binding activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; jaw; and limb primordium. Used to study generalized anxiety disorder. Orthologous to human ZNF462 (zinc finger protein 462). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.4), whole brain E14.5 (RPKM 11.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B2; 4 29.5 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (54942038..55083563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (54944491..55083563)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10263 Neighboring gene STARR-seq mESC enhancer starr_10264 Neighboring gene STARR-seq mESC enhancer starr_10265 Neighboring gene predicted gene, 34133 Neighboring gene TPX2, microtubule-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_10266 Neighboring gene STARR-seq mESC enhancer starr_10268 Neighboring gene STARR-seq mESC enhancer starr_10269 Neighboring gene predicted gene 8364 Neighboring gene STARR-seq mESC enhancer starr_10270 Neighboring gene STARR-seq mESC enhancer starr_10271 Neighboring gene STARR-seq mESC enhancer starr_10272 Neighboring gene STARR-seq mESC enhancer starr_10273 Neighboring gene STARR-seq mESC enhancer starr_10275 Neighboring gene predicted gene, 42289 Neighboring gene STARR-seq mESC enhancer starr_10277 Neighboring gene predicted gene 12514 Neighboring gene splicing factor, arginine/serine-rich 7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. Yelagandula R, et al. Nat Cell Biol, 2023 Jan. PMID 36604593, Free PMC Article
  2. ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate. Massé J, et al. Exp Cell Res, 2011 Aug 1. PMID 21570965
  3. Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA. Laurent A, et al. Mech Dev, 2007 May. PMID 17353115
  4. A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Skarnes WC, et al. Genes Dev, 1992 Jun. PMID 1592261
  5. Graded expression of Zfp462 in the embryonic mouse cerebral cortex. Chang YS, et al. Gene Expr Patterns, 2007 Feb. PMID 17207666

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
    Title: miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
  2. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
    Title: ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
  3. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
    Title: Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
  4. The ZFPIP/Zfp462 is a key chromatin factor involved in maintaining P19 pluripotency and in the early mechanisms of neural differentiation but that it is dispensable in differentiated P19 cells.
    Title: ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate.
  5. An instrumental role of ZFPIP/Zfp462 in maintaining the chromatin structure of pluripotent cells.
    Title: Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.
  6. Study shows that Zfp462 is expressed in the developing central nervous system, branchial arches, otic vesicles, sensory ganglia, somites and limbs.
    Title: Graded expression of Zfp462 in the embryonic mouse cerebral cortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 462
Names
gene trap insertion site 4-2
zinc finger PBX1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172867.4 → NP_766455.2  zinc finger protein 462

    See identical proteins and their annotated locations for NP_766455.2

    Status: VALIDATED

    Source sequence(s)
    AL772186, AL844140
    Consensus CDS
    CCDS38764.1
    UniProtKB/Swiss-Prot
    A2SW42, B1AWL2
    Related
    ENSMUSP00000095677.4, ENSMUST00000098070.10
    Conserved Domains (2) summary
    sd00017
    Location:2016 → 2036
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2014 → 2038
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    54942038..55083563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253536.2 → XP_030109396.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_006537917.5 → XP_006537980.1  zinc finger protein 462 isoform X1

    See identical proteins and their annotated locations for XP_006537980.1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_036164123.1 → XP_036020016.1  zinc finger protein 462 isoform X11

    Conserved Domains (2) summary
    sd00017
    Location:1155 → 1175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1153 → 1177
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_036164113.1 → XP_036020006.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  5. XM_030253535.2 → XP_030109395.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  6. XM_006537915.3 → XP_006537978.1  zinc finger protein 462 isoform X1

    See identical proteins and their annotated locations for XP_006537978.1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  7. XM_030253545.2 → XP_030109405.1  zinc finger protein 462 isoform X9

    Conserved Domains (2) summary
    sd00017
    Location:1216 → 1236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1214 → 1238
    zf-H2C2_5; C2H2-type zinc-finger domain

  8. XM_036164124.1 → XP_036020017.1  zinc finger protein 462 isoform X11

    Conserved Domains (2) summary
    sd00017
    Location:1155 → 1175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1153 → 1177
    zf-H2C2_5; C2H2-type zinc-finger domain

  9. XM_030253546.2 → XP_030109406.1  zinc finger protein 462 isoform X11

    Conserved Domains (2) summary
    sd00017
    Location:1155 → 1175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1153 → 1177
    zf-H2C2_5; C2H2-type zinc-finger domain

  10. XM_030253534.2 → XP_030109394.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  11. XM_006537916.3 → XP_006537979.1  zinc finger protein 462 isoform X1

    See identical proteins and their annotated locations for XP_006537979.1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  12. XM_030253537.2 → XP_030109397.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  13. XM_006537919.4 → XP_006537982.1  zinc finger protein 462 isoform X1

    See identical proteins and their annotated locations for XP_006537982.1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  14. XM_036164112.1 → XP_036020005.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  15. XM_006537918.5 → XP_006537981.1  zinc finger protein 462 isoform X1

    See identical proteins and their annotated locations for XP_006537981.1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  16. XM_036164111.1 → XP_036020004.1  zinc finger protein 462 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:2077 → 2097
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  17. XM_036164118.1 → XP_036020011.1  zinc finger protein 462 isoform X6

    Conserved Domains (2) summary
    sd00017
    Location:2043 → 2063
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

  18. XM_036164115.1 → XP_036020008.1  zinc finger protein 462 isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:2040 → 2060
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2038 → 2062
    zf-H2C2_5; C2H2-type zinc-finger domain

  19. XM_036164114.1 → XP_036020007.1  zinc finger protein 462 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:2076 → 2096
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2074 → 2098
    zf-H2C2_5; C2H2-type zinc-finger domain

  20. XM_036164116.1 → XP_036020009.1  zinc finger protein 462 isoform X4

    Conserved Domains (2) summary
    sd00017
    Location:2039 → 2059
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2037 → 2061
    zf-H2C2_5; C2H2-type zinc-finger domain

  21. XM_036164117.1 → XP_036020010.1  zinc finger protein 462 isoform X5

    UniProtKB/Swiss-Prot
    A2SW42, B1AWL2
    Conserved Domains (2) summary
    sd00017
    Location:2016 → 2036
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2014 → 2038
    zf-H2C2_5; C2H2-type zinc-finger domain

  22. XM_036164119.1 → XP_036020012.1  zinc finger protein 462 isoform X7

    Conserved Domains (2) summary
    sd00017
    Location:2016 → 2036
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2014 → 2038
    zf-H2C2_5; C2H2-type zinc-finger domain

  23. XM_036164121.1 → XP_036020014.1  zinc finger protein 462 isoform X9

    Conserved Domains (2) summary
    sd00017
    Location:1216 → 1236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1214 → 1238
    zf-H2C2_5; C2H2-type zinc-finger domain

  24. XM_036164122.1 → XP_036020015.1  zinc finger protein 462 isoform X10

    Conserved Domains (2) summary
    sd00017
    Location:1215 → 1235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:1213 → 1237
    zf-H2C2_5; C2H2-type zinc-finger domain

  25. XM_036164120.1 → XP_036020013.1  zinc finger protein 462 isoform X8

    Conserved Domains (2) summary
    sd00017
    Location:2043 → 2063
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13909
    Location:2075 → 2099
    zf-H2C2_5; C2H2-type zinc-finger domain

RNA

  1. XR_004941892.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AWL2.1 GenPept UniProtKB/Swiss-Prot:B1AWL2

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