Alb albumin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Albprovided by RGD
Official Full Name: albuminprovided by RGD
Primary source: RGD:2085
See related: Ensembl:ENSRNOG00000002911 AllianceGenome:RGD:2085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alb1; Albza
Summary: Enables several functions, including fatty acid binding activity; modified amino acid binding activity; and zinc ion binding activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, non-REM sleep; response to mercury ion; and response to platinum ion. Located in basement membrane and extracellular space. Used to study familial hyperlipidemia. Biomarker of Reye syndrome; obstructive jaundice; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; hepatobiliary system cancer (multiple); hyperthyroxinemia; middle cerebral artery infarction; and psoriasis. Orthologous to human ALB (albumin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 349119.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (17891564..17907043, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (17607397..17622814, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (19176275..19191793, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Predictive value of ischaemia-modified albumin in spermatogenesis in an experimental testicular torsion model.
Title: Predictive value of ischaemia-modified albumin in spermatogenesis in an experimental testicular torsion model.
Tubular Expression and Urinary Excretion of MMP-9 Protein Were Increased in Association with Albumin Overload in the Diabetic Kidneys.
Title: Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
albumin immunoreactivity was newly observed in microglia in the hippocampal CA1 region following 5 min of transient cerebral ischemia. These results indicate that transient ischemia-induced albumin expression in microglia might be associated with ischemia-induced 'delayed neuronal death' in the hippocampal CA1 pyramidal neurons.
Title: Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus.
significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.
Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3
Title: Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.
Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation.
Title: Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.
Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha.
Title: Combined effect of insulin and high glucose concentration on albumin permeability in cultured rat podocytes.
Overall, rats with albumin deficiency display enhanced glucose tolerance, insulin secretion and gluconeogenic flux.
Title: Enhanced insulin secretion and glucose tolerance in rats exhibiting low plasma free fatty acid levels and hypertriglyceridaemia due to congenital albumin deficiency.
albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase
Title: Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo.
Data indicate that transcription of Alb is regulated by a complicated system of distant enhancers.
Title: Systematic targeted integration to study Albumin gene control elements.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Alb1 (e-PCR), detects polymorphism
- UniSTS:141069

D14Wox11 (e-PCR)
- UniSTS:118050

D14Arb4 (e-PCR), detects polymorphism
- UniSTS:226598

D14Wox10 (e-PCR)
- UniSTS:118107

PMC86057P4 (e-PCR)
- UniSTS:273516

UniSTS:465369 (e-PCR)
- UniSTS:465369

Alb (e-PCR), detects polymorphism
- UniSTS:465369

PMC275467P2 (e-PCR)
- UniSTS:272383

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enterobactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables enterobactin binding	IEA Inferred from Electronic Annotation more info
enables enterobactin binding	ISO Inferred from Sequence Orthology more info
enables enterobactin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables exogenous protein binding	IEA Inferred from Electronic Annotation more info
enables exogenous protein binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables modified amino acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info
contributes_to oxygen binding	ISO Inferred from Sequence Orthology more info
contributes_to oxygen binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	IEA Inferred from Electronic Annotation more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial depolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in response to biphenyl	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to platinum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasodilation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: albumin

Names: serum albumin

NP_599153.2

EC 6.1.1.16

XP_063128922.1

EC 6.1.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.