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Vsig8 V-set and immunoglobulin domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 240916, updated on 12-May-2024

Summary

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Official Symbol
Vsig8provided by MGI
Official Full Name
V-set and immunoglobulin domain containing 8provided by MGI
Primary source
MGI:MGI:3642995
See related
Ensembl:ENSMUSG00000049598 AllianceGenome:MGI:3642995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG240916; A030011M19
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in metanephros; ovary; submandibular gland; testis; and trachea. Orthologous to human VSIG8 (V-set and immunoglobulin domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 20.9), testis adult (RPKM 4.9) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.95 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172383505..172391284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172555938..172563717)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transgelin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene cilia and flagella associated protein 45 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068 Neighboring gene SLAM family member 8 Neighboring gene Fc receptor-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. Rice RH, et al. J Invest Dermatol, 2011 Sep. PMID 21614015, Free PMC Article
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VSIG8 is found in the hair follicle, nails and oral cavity.
    Title: Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-set and immunoglobulin domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177723.4 → NP_808391.2  V-set and immunoglobulin domain-containing protein 8 precursor

    See identical proteins and their annotated locations for NP_808391.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AK037228, AW986342, BC064106
    Consensus CDS
    CCDS15516.1
    UniProtKB/Swiss-Prot
    Q6P3A4
    Related
    ENSMUSP00000058008.4, ENSMUST00000061835.10
    Conserved Domains (2) summary
    cd00096
    Location:29 → 34
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:28 → 129
    Ig; Immunoglobulin domain

RNA

  1. NR_027644.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. The longest ORF of the resulting transcript would encode a protein with a shorter N-terminus compared to the protein encoded by variant 1. However, there is an upstream ORF (uORF) in variant 2 that overlaps the translational start site of the longest ORF. The uORF has a strong Kozak signal and presumably prevents translation of the long ORF. Therefore, the transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is likely not protein-coding.
    Source sequence(s)
    AW986342, BC064106
    Related
    ENSMUST00000177086.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172383505..172391284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496856.5 → XP_006496919.1  V-set and immunoglobulin domain-containing protein 8 isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:160 → 250
    Ig; Immunoglobulin domain
    pfam07686
    Location:33 → 139
    V-set; Immunoglobulin V-set domain

  2. XM_006496857.5 → XP_006496920.1  V-set and immunoglobulin domain-containing protein 8 isoform X2

    Conserved Domains (2) summary
    cd00096
    Location:148 → 238
    Ig; Immunoglobulin domain
    pfam07686
    Location:21 → 127
    V-set; Immunoglobulin V-set domain

  3. XM_006496858.4 → XP_006496921.1  V-set and immunoglobulin domain-containing protein 8 isoform X3

    Conserved Domains (2) summary
    cd00096
    Location:131 → 221
    Ig; Immunoglobulin domain
    pfam07686
    Location:4 → 110
    V-set; Immunoglobulin V-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3A4.2 GenPept UniProtKB/Swiss-Prot:Q6P3A4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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