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Slc4a9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 [ Mus musculus (house mouse) ]

Gene ID: 240215, updated on 22-Apr-2024

Summary

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Official Symbol
Slc4a9provided by MGI
Official Full Name
solute carrier family 4, sodium bicarbonate cotransporter, member 9provided by MGI
Primary source
MGI:MGI:2443384
See related
Ensembl:ENSMUSG00000024485 AllianceGenome:MGI:2443384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AE4; AE 4; D630003B07; D630024F24Rik
Summary
Predicted to enable anion:anion antiporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Located in apical part of cell and membrane. Is expressed in ureteric trunk. Orthologous to human SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 38.1) See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.46 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36661117..36689325)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36528066..36556272)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44284 Neighboring gene prefoldin 1 Neighboring gene STARR-seq mESC enhancer starr_44287 Neighboring gene STARR-seq mESC enhancer starr_44288 Neighboring gene STARR-seq mESC enhancer starr_44290 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene predicted gene, 41698 Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_44296 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene eukaryotic translation initiation factor 4E binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The AE4 transporter mediates kidney acid-base sensing. Vitzthum H, et al. Nat Commun, 2023 May 26. PMID 37236964, Free PMC Article
  2. The murine AE4 promoter predominantly drives type B intercalated cell specific transcription. Hentschke M, et al. Histochem Cell Biol, 2009 Oct. PMID 19544066
  3. AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Ko SB, et al. Am J Physiol Cell Physiol, 2002 Oct. PMID 12225984
  4. Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO(3)(-) exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells. Peña-Münzenmayer G, et al. Am J Physiol Gastrointest Liver Physiol, 2021 Dec 1. PMID 34585968, Free PMC Article
  5. Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. Peña-Münzenmayer G, et al. J Biol Chem, 2015 Apr 24. PMID 25745107, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel functions of the anion exchanger AE4 (SLC4A9).
    Title: Novel functions of the anion exchanger AE4 (SLC4A9).
  2. The AE4 transporter mediates kidney acid-base sensing.
    Title: The AE4 transporter mediates kidney acid-base sensing.
  3. Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO3(-) exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells.
    Title: Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO(3)(-) exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells.
  4. both Ae2 and Ae4 anion exchangers are functionally expressed in submandibular acinar cells; however, only Ae4 expression appears to be important for cAMP-dependent regulation of fluid secretion
    Title: Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells.
  5. a promoter, which can recapitulate the expression of endogenous AE4 in type B intercalated cells, was identified.
    Title: The murine AE4 promoter predominantly drives type B intercalated cell specific transcription.
  6. The AE4 promoter is identified as a direct target of Foxi1.
    Title: The forkhead transcription factor Foxi1 directly activates the AE4 promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride:bicarbonate antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium,bicarbonate:chloride antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:bicarbonate symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in saliva secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anion exchange protein 4
Names
anion exchanger 4
solute carrier family 4 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271544.1 → NP_001258473.1  anion exchange protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001258473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK085269, AK085424, AK142545
    Consensus CDS
    CCDS89223.1
    UniProtKB/Swiss-Prot
    A0A494BA31
    UniProtKB/TrEMBL
    Q14DJ1
    Related
    ENSMUSP00000157862.2, ENSMUST00000236124.2
    Conserved Domains (3) summary
    TIGR00834
    Location:53 → 907
    ae; anion exchange protein
    pfam00955
    Location:349 → 860
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84 → 300
    Band_3_cyto; Band 3 cytoplasmic domain

  2. NM_001271545.1 → NP_001258474.1  anion exchange protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC147220, AK085269, AK085424, AK142545, BC113179
    Consensus CDS
    CCDS70884.1
    UniProtKB/TrEMBL
    E9PUP3, Q14DJ1
    Related
    ENSMUSP00000158071.2, ENSMUST00000237174.2
    Conserved Domains (3) summary
    TIGR00834
    Location:53 → 884
    ae; anion exchange protein
    pfam00955
    Location:349 → 837
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84 → 300
    Band_3_cyto; Band 3 cytoplasmic domain

  3. NM_001271546.1 → NP_001258475.1  anion exchange protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon compared to isoform 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC147220, AK085269, AK085424, AK142545, BC113785
    Consensus CDS
    CCDS89222.1
    UniProtKB/TrEMBL
    A0A494BBC3, Q14DJ1
    Related
    ENSMUSP00000158410.2, ENSMUST00000236126.2
    Conserved Domains (3) summary
    TIGR00834
    Location:53 → 873
    ae; anion exchange protein
    pfam00955
    Location:349 → 826
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84 → 300
    Band_3_cyto; Band 3 cytoplasmic domain

  4. NM_001271547.1 → NP_001258476.1  anion exchange protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001258476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons and differs in the 3' UTR compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC147220, AK142545
    Consensus CDS
    CCDS89224.1
    UniProtKB/TrEMBL
    A0A494BAI0, Q3UQE1
    Related
    ENSMUSP00000158033.2, ENSMUST00000236779.2
    Conserved Domains (1) summary
    cl26877
    Location:53 → 802
    Band_3_cyto; Band 3 cytoplasmic domain

  5. NM_172830.2 → NP_766418.1  anion exchange protein 4 isoform 3

    See identical proteins and their annotated locations for NP_766418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon, that causes a frameshift. It also lacks the next exon, which restores the correct reading frame. The resulting isoform (3) has a shorter, alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC147220, AK085269
    Consensus CDS
    CCDS29154.1
    UniProtKB/TrEMBL
    Q14DJ1, Q8BUG8
    Related
    ENSMUSP00000157460.2, ENSMUST00000235181.2
    Conserved Domains (3) summary
    TIGR00834
    Location:53 → 835
    ae; anion exchange protein
    pfam00955
    Location:385 → 788
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:84 → 300
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36661117..36689325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525907.5 → XP_006525970.1  anion exchange protein 4 isoform X2

    UniProtKB/TrEMBL
    Q14DJ1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 874
    Band_3_cyto; Band 3 cytoplasmic domain

  2. XM_006525910.5 → XP_006525973.1  anion exchange protein 4 isoform X5

    UniProtKB/TrEMBL
    Q3UQE1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 803
    Band_3_cyto; Band 3 cytoplasmic domain

  3. XM_006525908.5 → XP_006525971.1  anion exchange protein 4 isoform X3

    UniProtKB/TrEMBL
    Q14DJ1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 856
    Band_3_cyto; Band 3 cytoplasmic domain

  4. XM_006525909.5 → XP_006525972.1  anion exchange protein 4 isoform X4

    UniProtKB/TrEMBL
    Q14DJ1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 836
    Band_3_cyto; Band 3 cytoplasmic domain

  5. XM_006525911.5 → XP_006525974.1  anion exchange protein 4 isoform X8

    UniProtKB/TrEMBL
    Q3UQE1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 803
    Band_3_cyto; Band 3 cytoplasmic domain

  6. XM_011246920.4 → XP_011245222.1  anion exchange protein 4 isoform X9

    UniProtKB/TrEMBL
    Q3UQE1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 803
    Band_3_cyto; Band 3 cytoplasmic domain

  7. XM_017317896.3 → XP_017173385.1  anion exchange protein 4 isoform X7

    UniProtKB/TrEMBL
    Q14DJ1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 805
    Band_3_cyto; Band 3 cytoplasmic domain

  8. XM_006525906.5 → XP_006525969.1  anion exchange protein 4 isoform X1

    UniProtKB/TrEMBL
    Q14DJ1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 908
    Band_3_cyto; Band 3 cytoplasmic domain

  9. XM_011246919.4 → XP_011245221.1  anion exchange protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011245221.1

    UniProtKB/TrEMBL
    A0A494BAI0, Q3UQE1
    Conserved Domains (1) summary
    cl26877
    Location:53 → 802
    Band_3_cyto; Band 3 cytoplasmic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A494BA31.1 GenPept UniProtKB/Swiss-Prot:A0A494BA31

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