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Fsd1 fibronectin type 3 and SPRY domain-containing protein [ Mus musculus (house mouse) ]

Gene ID: 240121, updated on 5-Mar-2024

Summary

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Official Symbol
Fsd1provided by MGI
Official Full Name
fibronectin type 3 and SPRY domain-containing proteinprovided by MGI
Primary source
MGI:MGI:1934858
See related
Ensembl:ENSMUSG00000011589 AllianceGenome:MGI:1934858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization; regulation of cytokinesis; and regulation of mitotic spindle organization. Predicted to act upstream of or within cell division. Predicted to be located in centrosome and microtubule. Is expressed in nervous system and sensory organ. Orthologous to human FSD1 (fibronectin type III and SPRY domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 45.8), whole brain E14.5 (RPKM 38.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Fsd1 in Genome Data Viewer
Location:
17 D; 17 29.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56293475..56303881)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55986462..55996883)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16712 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene signal transducing adaptor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2497 Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Baneyx G, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11959962, Free PMC Article
  2. Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. Carim-Todd L, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267680
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension
    Title: Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC58341

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III and SPRY domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411202.1 → NP_001398131.1  fibronectin type III and SPRY domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009719

  2. NM_001411203.1 → NP_001398132.1  fibronectin type III and SPRY domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT009719

  3. NM_001411204.1 → NP_001398133.1  fibronectin type III and SPRY domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT009719

  4. NM_001411205.1 → NP_001398134.1  fibronectin type III and SPRY domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT009719

  5. NM_001411206.1 → NP_001398135.1  fibronectin type III and SPRY domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT009719

  6. NM_001411207.1 → NP_001398136.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT009719

  7. NM_001411208.1 → NP_001398137.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT009719

  8. NM_001411209.1 → NP_001398138.1  fibronectin type III and SPRY domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT009719

  9. NM_183178.3 → NP_899001.1  fibronectin type III and SPRY domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_899001.1

    Status: VALIDATED

    Source sequence(s)
    CT009719
    Consensus CDS
    CCDS37661.1
    UniProtKB/Swiss-Prot
    Q3UNE6, Q7TPM6
    Related
    ENSMUSP00000011733.9, ENSMUST00000011733.9
    Conserved Domains (3) summary
    cd00063
    Location:165 → 265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270 → 476
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:4 → 120
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RNA

  1. NR_177196.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009719

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56293475..56303881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPM6.1 GenPept UniProtKB/Swiss-Prot:Q7TPM6

Gene LinkOut

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