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Zfp647 zinc finger protein 647 [ Mus musculus (house mouse) ]

Gene ID: 239546, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp647provided by MGI
Official Full Name
zinc finger protein 647provided by MGI
Primary source
MGI:MGI:3052806
See related
Ensembl:ENSMUSG00000054967 AllianceGenome:MGI:3052806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Es492; Znf250; 6030449J21
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; limb; nervous system; and retina. Orthologous to human ZNF250 (zinc finger protein 250). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 7.2), CNS E14 (RPKM 6.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76794570..76809907, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76910370..76925693, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E5492 Neighboring gene COMM domain containing 5 Neighboring gene ribosomal protein L8 Neighboring gene zinc finger protein 113 pseudogene Neighboring gene predicted gene, 46534 Neighboring gene RIKEN cDNA 1110038F14 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies. Briers S, et al. J Cell Sci, 2009 Apr 1. PMID 19258395, Free PMC Article
  2. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 250
Names
KRAB zinc-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168276.2 → NP_001161748.1  zinc finger protein 250

    See identical proteins and their annotated locations for NP_001161748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS27596.1
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57
    Conserved Domains (3) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:172 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001416083.1 → NP_001403012.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  3. NM_001416084.1 → NP_001403013.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  4. NM_001416085.1 → NP_001403014.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  5. NM_001416086.1 → NP_001403015.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  6. NM_001416087.1 → NP_001403016.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  7. NM_001416088.1 → NP_001403017.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  8. NM_001416089.1 → NP_001403018.1  zinc finger protein 250

    Status: VALIDATED

    Source sequence(s)
    AC157554
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57

  9. NM_172817.4 → NP_766405.2  zinc finger protein 250

    See identical proteins and their annotated locations for NP_766405.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC157554
    Consensus CDS
    CCDS27596.1
    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57
    Related
    ENSMUSP00000155685.2, ENSMUST00000229055.2
    Conserved Domains (3) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:172 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76794570..76809907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159398.1 → XP_036015291.1  zinc finger protein 250 isoform X1

    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57
    Conserved Domains (3) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:172 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030248551.2 → XP_030104411.1  zinc finger protein 250 isoform X1

    UniProtKB/Swiss-Prot
    Q7TNU6, Q8BJ57
    Conserved Domains (3) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:172 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:176 → 196
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNU6.1 GenPept UniProtKB/Swiss-Prot:Q7TNU6

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